Characteristics and Correlations of the Oral and Gut Fungal Microbiome with Hypertension/Experiment 6

From BugSigDB


Reviewed Marked as Reviewed by Folakunmi on 2025-1-3

Curated date: 2024/04/12

Curator: Rahila

Revision editor(s): Rahila, Folakunmi

Subjects

Location of subjects
China
Host species Species from which microbiome was sampled. Contact us to have more species added.
Homo sapiens
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Hypertension (hypertensive disease) or (hypertension),[X]Hypertensive diseases,[X]Hypertensive diseases (disorder),Blood Pressure, High,blood pressure, high,blood pressure, increased,Blood Pressures, High,High Blood Pressure,high blood pressure,High blood pressure (& [essential hypertension]),High Blood Pressures,HTN,HTN - hypertension,hyperpiesia,hypertension,hypertension NOS,HYPERTENSIVE DISEASE,hypertensive disease,Hypertensive disease (disorder),hypertensive disease NOS,Hypertensive disease NOS (disorder),hypertensive disorder,increased blood pressure,pressure, high blood,SURG COMP - HYPERTENSION,vascular hypertensive disorder,Hypertension
Group 0 name Corresponds to the control (unexposed) group for case-control studies
no-Hypertension (no-HTN)
Group 1 name Corresponds to the case (exposed) group for case-control studies
Hypertension (HTN)
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
Participants with Hypertension (HTN)
Group 0 sample size Number of subjects in the control (unexposed) group
24
Group 1 sample size Number of subjects in the case (exposed) group
36
Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
2 months

Lab analysis

Sequencing type
WMS
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
Not specified
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
Illumina

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
relative abundances
Statistical test
LEfSe
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
No
LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
2

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
unchanged
Chao1 Abundance-based estimator of species richness
increased
Simpson Estimator of species richness and species evenness: more weight on species evenness
unchanged
Richness Number of species
unchanged

Signature 1

Reviewed Marked as Reviewed by Folakunmi on 2025-1-3

Curated date: 2024/04/12

Curator: Rahila

Revision editor(s): Rahila, Folakunmi

Source: FIG 3 (C)

Description: Different fungal enrichments in the faecal samples between the HTN and no-HTN groups.

Abundance in Group 1: increased abundance in Hypertension (HTN)

NCBI Quality ControlLinks
Aspergillus fumigatus
Aspergillus nomiae
Aspergillus terreus
Colletotrichum
Colletotrichum higginsianum
Cryptococcaceae
Cryptococcus
Glomerellaceae
Komagataella
Komagataella phaffii
Spizellomyces
Spizellomyces punctatus
Spizellomycetaceae
Spizellomycetales
Torulaspora
Torulaspora delbrueckii
Tremellales
Tremellomycetes
Trichoderma reesei
Trichoderma virens
unclassified Cryptococcus (in: basidiomycete fungi)
unclassified Dothideomycetes

Revision editor(s): Rahila, Folakunmi

Signature 2

Reviewed Marked as Reviewed by Folakunmi on 2025-1-13

Curated date: 2024/04/12

Curator: Rahila

Revision editor(s): Rahila, Folakunmi

Source: FIG 3 (C)

Description: Different fungal enrichments in the faecal samples between the HTN and no-HTN groups.

Abundance in Group 1: decreased abundance in Hypertension (HTN)

NCBI Quality ControlLinks
Chaetothyriales
Coniophora
Coniophora puteana
Coniophoraceae
Herpotrichiellaceae
Sordariales
Talaromyces pinophilus

Revision editor(s): Rahila, Folakunmi