Transplantation of gut microbiota derived from patients with schizophrenia induces schizophrenia-like behaviors and dysregulated brain transcript response in mice/Experiment 2
From BugSigDB
Reviewed Marked as Reviewed by Svetlana up on 2024-7-18
Curated date: 2024/07/16
Curator: Jacob A. De Jesus
Revision editor(s): Jacob A. De Jesus, Scholastica
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Mus musculus
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Schizophrenia [X]Schizophrenia, unspecified,[X]Schizophrenia, unspecified (disorder),Dementia Praecox,Disorder, Schizophrenic,Disorders, Schizophrenic,Other specified types of schizophrenia,Other specified types of schizophrenia, chronic state,Other specified types of schizophrenia, chronic state with acute exacerbation,Other specified types of schizophrenia, in remission,Other specified types of schizophrenia, subchronic state,Other specified types of schizophrenia, subchronic state with acute exacerbation,Other specified types of schizophrenia, unspecified state,SCHIZO NEC-CHR/EXACERB,SCHIZO NEC-SUBCHR/EXACER,SCHIZO NOS-CHR/EXACERB,SCHIZO NOS-SUBCHR/EXACER,schizoaffective disorder,schizophrenia,schizophrenia (disease),Schizophrenia (disorder),SCHIZOPHRENIA NEC-CHR,SCHIZOPHRENIA NEC-REMISS,SCHIZOPHRENIA NEC-SUBCHR,SCHIZOPHRENIA NEC-UNSPEC,Schizophrenia NOS,Schizophrenia NOS (disorder),SCHIZOPHRENIA NOS-UNSPEC,schizophrenia with or without an affective disorder,Schizophrenia, NOS,schizophrenia-1,Schizophrenias,SCHIZOPHRENIC DIS,Schizophrenic Disorder,Schizophrenic Disorders,Schizophrenic disorders (disorder),SCZD,Unspecified schizophrenia,Unspecified schizophrenia (disorder),Unspecified schizophrenia, chronic state with acute exacerbation,Unspecified schizophrenia, subchronic state with acute exacerbation,Unspecified schizophrenia, unspecified state,Schizophrenia
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- HC: healthy control fecal microbiota-recipient mice
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- SCZ: schizophrenia fecal microbiota-recipient mice
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Male C57BL/6 mice which transplanted fecal microbiota from a human patient with a schizophrenia psychiatric disorder.
- Group 0 sample size Number of subjects in the control (unexposed) group
- 5
- Group 1 sample size Number of subjects in the case (exposed) group
- 5
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V3-V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- LEfSe
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
Signature 1
Reviewed Marked as Reviewed by Svetlana up on 2024-7-18
Curated date: 2024/07/16
Curator: Jacob A. De Jesus
Revision editor(s): Jacob A. De Jesus, Scholastica
Source: Figure 4D
Description: Bacterial genera differentially expressed in mice transplanted with schizophrenia versus healthy control fecal microbiota
Abundance in Group 1: increased abundance in SCZ: schizophrenia fecal microbiota-recipient mice
Revision editor(s): Jacob A. De Jesus, Scholastica
Signature 2
Reviewed Marked as Reviewed by Svetlana up on 2024-7-18
Curated date: 2024/07/16
Curator: Jacob A. De Jesus
Revision editor(s): Jacob A. De Jesus, Scholastica
Source: Figure 4D
Description: Bacterial genera differentially expressed in mice transplanted with schizophrenia versus healthy control fecal microbiota
Abundance in Group 1: decreased abundance in SCZ: schizophrenia fecal microbiota-recipient mice
| NCBI | Quality Control | Links |
|---|---|---|
| Alistipes | ||
| Bacteroides | ||
| Christensenella | ||
| Lactobacillus | ||
| Parabacteroides | ||
| Thomasclavelia |
Revision editor(s): Jacob A. De Jesus, Scholastica
