Gut microbial biomarkers for the treatment response in first-episode, drug-naïve schizophrenia: a 24-week follow-up study/Experiment 1
From BugSigDB
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Response to risperidone Response to risperidone,response to risperidone
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Healthy controls (C)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Schizophrenia (SCH) patients at Baseline (S0)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Schizophrenia drug-naïve patients who were newly admitted, and no treatment had begun. Patients had not yet received risperidone.
- Group 0 sample size Number of subjects in the control (unexposed) group
- 107
- Group 1 sample size Number of subjects in the case (exposed) group
- 107
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- 30 days
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V3-V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Ion Torrent
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- Mann-Whitney (Wilcoxon)
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
- Matched on Factors on which subjects have been matched on in a case-control study
- age, body mass index, smoking behavior, education level, sex
- Confounders controlled for Confounding factors that have been accounted for by stratification or model adjustment
- age, body mass index, smoking behavior, education level, sex
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- decreased
- Chao1 Abundance-based estimator of species richness
- unchanged
- Simpson Estimator of species richness and species evenness: more weight on species evenness
- decreased
- Richness Number of species
- unchanged
- Faith Phylogenetic diversity, takes into account phylogenetic distance of all taxa identified in a sample
- increased
Signature 1
Source: Figure 4c and Supplementary Table 3
Description: Taxa enriched in the gut microbiota of Schizophrenia (SCH) patients at Baseline (S0) and Healthy controls (C).
Abundance in Group 1: increased abundance in Schizophrenia (SCH) patients at Baseline (S0)
| NCBI | Quality Control | Links |
|---|---|---|
| Lachnoclostridium |
Signature 2
Source: Figure 4d and Supplementary Table 3
Description: Taxa enriched in the gut microbiota of Schizophrenia (SCH) patients at Baseline (S0) and Healthy controls (C).
Abundance in Group 1: decreased abundance in Schizophrenia (SCH) patients at Baseline (S0)
