Gut microbial biomarkers for the treatment response in first-episode, drug-naïve schizophrenia: a 24-week follow-up study/Experiment 6
From BugSigDB
Reviewed Marked as Reviewed by Svetlana up on 2024-12-16
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Response to risperidone Response to risperidone,response to risperidone
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Schizophrenia (SCH) patients at Baseline (S0)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Schizophrenia (SCH) patients at Week 24 (S3)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Schizophrenia drug-naïve patients who had received 24 weeks of risperidone treatment and were accessed after the treatment.
- Group 0 sample size Number of subjects in the control (unexposed) group
- 107
- Group 1 sample size Number of subjects in the case (exposed) group
- 60
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- 30 Days
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V3-V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Ion Torrent
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- LEfSe
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
- LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
- 3
- Matched on Factors on which subjects have been matched on in a case-control study
- age, body mass index, smoking behavior, education level, sex
- Confounders controlled for Confounding factors that have been accounted for by stratification or model adjustment
- age, body mass index, education level, sex, smoking behavior, Confounders controlled for: "disease duration" is not in the list (abnormal glucose tolerance, acetaldehyde, acute graft vs. host disease, acute lymphoblastic leukemia, acute myeloid leukemia, adenoma, age, AIDS, alcohol consumption measurement, alcohol drinking, ...) of allowed values.disease duration
Signature 1
Reviewed Marked as Reviewed by Svetlana up on 2024-12-16
Source: Supplementary Figure S5
Description: Taxa enriched in the gut microbiota of Schizophrenia (SCH) patients at Baseline(S0) and After treatment at Week 24 (S3)
Abundance in Group 1: increased abundance in Schizophrenia (SCH) patients at Week 24 (S3)
Revision editor(s): MyleeeA
Signature 2
Reviewed Marked as Reviewed by Svetlana up on 2024-12-16
Source: Supplementary Figure 5 and Figure 4c
Description: Taxa enriched in the gut microbiota of Schizophrenia patients at Baseline(S0) and After treatment at Week 24 (S3)
Abundance in Group 1: decreased abundance in Schizophrenia (SCH) patients at Week 24 (S3)
| NCBI | Quality Control | Links |
|---|---|---|
| Lachnoclostridium |
Revision editor(s): Aleru Divine, MyleeeA
