Oral and gut microbial profiling in periodontitis and Parkinson's disease/Experiment 9
From BugSigDB
Reviewed Marked as Reviewed by Svetlana up on 2024-11-20
Subjects
- Location of subjects
- Turkey
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Saliva , Feces Sailva normalis,Saliva atomaris,Saliva molecularis,Salivary gland secretion,Saliva,saliva,Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Periodontitis chronic pericementitis,inflammation of periodontium,Pericementitides,Pericementitis,Periodontitides,periodontitis,Periodontitis (disorder),Periodontitis, NOS,periodontium inflammation,periodontosis,Periodontitis
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Parkinson's disease + Periodontitis group (PA + P) (Feces)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Parkinson's disease + Periodontitis group (PA + P) (Saliva)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Saliva samples collected from Parkinson's disease + Periodontitis group (PA + P) participants.
- Group 0 sample size Number of subjects in the control (unexposed) group
- 16
- Group 1 sample size Number of subjects in the case (exposed) group
- 16
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- 3 months
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V1-V3
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- LEfSe
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
- LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
- 2.0
Signature 1
Reviewed Marked as Reviewed by Svetlana up on 2024-11-20
Source: Supplementary File 2c
Description: LefSe results representing significant difference in relative abundance in fecal and saliva samples from Periodontitis patients with Parkinson's disease (PA + P).
Abundance in Group 1: increased abundance in Parkinson's disease + Periodontitis group (PA + P) (Saliva)
Revision editor(s): Aleru Divine, Svetlana up
Signature 2
Reviewed Marked as Reviewed by Svetlana up on 2024-11-20
Source: Supplementary File 2
Description: LefSe results representing significant difference in relative abundance in fecal and saliva samples from Periodontitis patients with Parkinson's disease (PA + P).
Abundance in Group 1: decreased abundance in Parkinson's disease + Periodontitis group (PA + P) (Saliva)
Revision editor(s): MyleeeA, Aleru Divine
