Gut microbiota patterns associated with duration of diarrhea in children under five years of age in Ethiopia/Experiment 2

Needs review

Curated date: 2025/01/23

Curator: Miss Lulu

Revision editor(s): Miss Lulu

Host species Species from which microbiome was sampled. Contact us to have more species added.: Homo sapiens

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology: Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces

Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology: Diarrhea Diarrhea,Diarrhoea,Watery stool,diarrhea

Group 0 name Corresponds to the control (unexposed) group for case-control studies: Non-diarrheal controls.

Group 1 name Corresponds to the case (exposed) group for case-control studies: Acute Diarrhea

Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group: The aim of our study was to decipher what differentiates the GM of children with diarrhea (AD and ProPD) from healthy controls

Group 0 sample size Number of subjects in the control (unexposed) group: 663

16S variable region One or more hypervariable region(s) of the bacterial 16S gene: -V4

Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance: Illumina

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).: relative abundances

Significance threshold p-value or FDR threshold used for differential abundance testing (if any): 0.05

MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?: Yes

Matched on Factors on which subjects have been matched on in a case-control study: Matched on: "frequency" is not in the list (abnormal glucose tolerance, acetaldehyde, acute graft vs. host disease, acute lymphoblastic leukemia, acute myeloid leukemia, adenoma, age, AIDS, alcohol consumption measurement, alcohol drinking, ...) of allowed values.frequency

Confounders controlled for Confounding factors that have been accounted for by stratification or model adjustment: breast feeding, age, Confounders controlled for: "enrollment season" is not in the list (abnormal glucose tolerance, acetaldehyde, acute graft vs. host disease, acute lymphoblastic leukemia, acute myeloid leukemia, adenoma, age, AIDS, alcohol consumption measurement, alcohol drinking, ...) of allowed values.enrollment season, Confounders controlled for: "enrollment site" is not in the list (abnormal glucose tolerance, acetaldehyde, acute graft vs. host disease, acute lymphoblastic leukemia, acute myeloid leukemia, adenoma, age, AIDS, alcohol consumption measurement, alcohol drinking, ...) of allowed values.enrollment site, sex, Confounders controlled for: "WAM Index" is not in the list (abnormal glucose tolerance, acetaldehyde, acute graft vs. host disease, acute lymphoblastic leukemia, acute myeloid leukemia, adenoma, age, AIDS, alcohol consumption measurement, alcohol drinking, ...) of allowed values.WAM Index