Dysbiosis of Gut Microbiota and Short-Chain Fatty Acids in Acute Ischemic Stroke and the Subsequent Risk for Poor Functional Outcomes/Experiment 4
From BugSigDB
Reviewed Marked as Reviewed by Folakunmi on 2024-11-7
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Ischemic stroke Ischaemic stroke,Ischemic stroke,ischemic stroke
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Healthy control/mild AIS/ moderate AIS
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Severe acute ischemic stroke
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Ischemic stroke Patients with a NIHSS score >15 points
- Group 0 sample size Number of subjects in the control (unexposed) group
- 217
- Group 1 sample size Number of subjects in the case (exposed) group
- 15
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- No antibiotic, probiotics or prebiotic taken in the past 3 months.
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- LEfSe
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
- LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
- 2.5
Signature 1
Reviewed Marked as Reviewed by Folakunmi on 2024-11-7
Source: figure 2D
Description: These taxa show increase in severe AIS compared to healthy control/mild AIS/moderate AIS by LEfSE
Abundance in Group 1: increased abundance in Severe acute ischemic stroke
| NCBI | Quality Control | Links |
|---|---|---|
| Porphyromonadaceae | ||
| Mycoplasmataceae | ||
| Phyllobacteriaceae | ||
| Carnobacteriaceae | ||
| Staphylococcaceae |
Revision editor(s): InimfonD
