Gut metagenomes of Asian octogenarians reveal metabolic potential expansion and distinct microbial species associated with aging phenotypes/Experiment 16
From BugSigDB
Reviewed Marked as Reviewed by ChiomaBlessing on 2024-11-14
Subjects
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Aging ageing,AGING BIOL,Aging, Biological,BIOL AGING,Biological Aging,Senescence,Aging,aging
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- SG90+CPE (Decreasing age group)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- SG90+CPE (Increased age group)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Dataset of Octogenarians community-living participants (not living in a nursing home, no diagnosis of dementia and not physically unfit) who consented to providing their stool and blood samples (SG90) and CPE-colonized subjects and their healthy family members (21–80 years old) with Chinese ethnicity.
- Group 0 sample size Number of subjects in the control (unexposed) group
- 69
- Group 1 sample size Number of subjects in the case (exposed) group
- 226
Lab analysis
- Sequencing type
- WMS
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- Not specified
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- Linear Regression
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
Signature 1
Reviewed Marked as Reviewed by ChiomaBlessing on 2024-11-14
Source: Supplementary Figure 3
Description: Microbial abundance in the SG90+CPE datasets significantly enriched with increase in Age. Using TSS Normalization and Linear model.
Abundance in Group 1: increased abundance in SG90+CPE (Increased age group)
| NCBI | Quality Control | Links |
|---|---|---|
| Alistipes indistinctus | ||
| Alistipes shahii | ||
| Bacteroides xylanisolvens | ||
| Parabacteroides merdae | ||
| Phocaeicola dorei | ||
| unclassified Alistipes |
Revision editor(s): MyleeeA
Signature 2
Reviewed Marked as Reviewed by ChiomaBlessing on 2024-11-14
Source: Supplementary File 3
Description: Microbial abundance in the SG90+CPE datasets enriched with decease in Age. Using TSS Normalization and Linear model.
Abundance in Group 1: decreased abundance in SG90+CPE (Increased age group)
Revision editor(s): MyleeeA, MaryAgekameh
