Differential effects of antiretrovirals on microbial translocation and gut microbiota composition of HIV-infected patients/Experiment 1/Signature 2
Source: Journal of the International AIDS Society
Description: The study investigates how different combinations of combined antiretroviral therapy (cART) impact bacterial translocation and gut microbiota in HIV-infected individuals. Conducted as a cross-sectional study with 45 HIV-infected patients, the research compares the effects of various cART regimens, including NRTIs combined with protease inhibitors, non-nucleoside reverse transcriptase inhibitors, and integrase strand transfer inhibitors. The findings reveal that the NRTIs + INSTIs regimen is associated with levels of systemic inflammation and microbial diversity similar to those of uninfected controls, while other regimens show varying impacts on gut microbiota composition. The study emphasizes the need for further longitudinal research to explore these relationships in depth.
Abundance in Group 1: decreased abundance in non-nucleoside reverse transcriptase inhibitors (NNRTIs)
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Revision editor(s): Joiejoie
