The human microbiota is associated with cardiometabolic risk across the epidemiologic transition/Experiment 21
From BugSigDB
Needs review
Subjects
- Location of subjects
- Ghana
- Jamaica
- South Africa
- United States of America
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Saliva Sailva normalis,Saliva atomaris,Saliva molecularis,Salivary gland secretion,Saliva,saliva
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Hypertension (hypertensive disease) or (hypertension),[X]Hypertensive diseases,[X]Hypertensive diseases (disorder),Blood Pressure, High,blood pressure, high,blood pressure, increased,Blood Pressures, High,High Blood Pressure,high blood pressure,High blood pressure (& [essential hypertension]),High Blood Pressures,HTN,HTN - hypertension,hyperpiesia,hypertension,hypertension NOS,HYPERTENSIVE DISEASE,hypertensive disease,Hypertensive disease (disorder),hypertensive disease NOS,Hypertensive disease NOS (disorder),hypertensive disorder,increased blood pressure,pressure, high blood,SURG COMP - HYPERTENSION,vascular hypertensive disorder,Hypertension
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Non-hypertension
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Hypertension
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- All participants from all countries (Jamaica, Ghana, South Africa and United States of America) with elevated blood pressure (hypertension).
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- centered log-ratio
- Statistical test
- ANCOM
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
- Confounders controlled for Confounding factors that have been accounted for by stratification or model adjustment
- age, body mass index, sex, Confounders controlled for: "country" is not in the list (abnormal glucose tolerance, acetaldehyde, acute graft vs. host disease, acute lymphoblastic leukemia, acute myeloid leukemia, adenoma, age, AIDS, alcohol consumption measurement, alcohol drinking, ...) of allowed values.country
Signature 1
Needs review
Source: Figure S18d
Description: Specific oral bacterial exact sequences variances (ESV) are differentially abundant between non-hypertensive and hypertensive participants in all countries.
Abundance in Group 1: increased abundance in Hypertension
| NCBI | Quality Control | Links |
|---|---|---|
| Prevotella | ||
| Veillonella |
Revision editor(s): Aleru Divine
Signature 2
Needs review
Source: Figure S18d
Description: Specific oral bacterial exact sequences variances (ESV) are differentially abundant between non-hypertensive and hypertensive participants in all countries.
Abundance in Group 1: decreased abundance in Hypertension
| NCBI | Quality Control | Links |
|---|---|---|
| Prevotella | ||
| Rothia |
Revision editor(s): Aleru Divine
