The human microbiota is associated with cardiometabolic risk across the epidemiologic transition/Experiment 26
From BugSigDB
Reviewed Marked as Reviewed by Svetlana up on 2024-12-14
Subjects
- Location of subjects
- United States of America
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Saliva Sailva normalis,Saliva atomaris,Saliva molecularis,Salivary gland secretion,Saliva,saliva
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Waist circumference Waist circumference,waist circumference
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Low waist circumference
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- High waist circumference
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- All participants from the United States of America with high waist circumference.
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- centered log-ratio
- Statistical test
- ANCOM
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
- Confounders controlled for Confounding factors that have been accounted for by stratification or model adjustment
- age, body mass index, sex, Confounders controlled for: "country" is not in the list (abnormal glucose tolerance, acetaldehyde, acute graft vs. host disease, acute lymphoblastic leukemia, acute myeloid leukemia, adenoma, age, AIDS, alcohol consumption measurement, alcohol drinking, ...) of allowed values.country
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- unchanged
Signature 1
Reviewed Marked as Reviewed by Svetlana up on 2024-12-14
Source: Figure S19a
Description: Specific oral bacterial exact sequences variances (ESV) are differentially abundant between high waist and low waist circumference groups in all participants from the United States of America.
Abundance in Group 1: increased abundance in High waist circumference
| NCBI | Quality Control | Links |
|---|---|---|
| Haemophilus | ||
| Neisseria | ||
| Prevotella |
Revision editor(s): Aleru Divine
Signature 2
Reviewed Marked as Reviewed by Svetlana up on 2024-12-14
Source: Figure S19a
Description: Specific oral bacterial exact sequences variances (ESV) are differentially abundant between high waist and low waist circumference groups in all participants from the United States of America.
Abundance in Group 1: decreased abundance in High waist circumference
| NCBI | Quality Control | Links |
|---|---|---|
| Porphyromonas |
Revision editor(s): Aleru Divine
