Changes in the nasopharyngeal and oropharyngeal microbiota in pediatric obstructive sleep apnea before and after surgery: a prospective study/Experiment 9
From BugSigDB
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Throat Gula,Throat,throat
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Obstructive sleep apnea Apnea, Obstructive Sleep,apnea, obstructive sleep,Apneas, Obstructive Sleep,Apneas, obstructive sleep,obstructive sleep apnea,Obstructive Sleep Apnea Syndrome,obstructive sleep apnea syndrome,Obstructive Sleep Apneas,obstructive sleep Apneas,Osa,OSAHS,sleep apnea hypopnea syndrome,Sleep Apnea Syndrome, Obstructive,sleep apnea syndrome, obstructive,Sleep Apnea, Obstructive,sleep apnea/hypopnea syndrome,Sleep Apneas, Obstructive,sleep Apneas, obstructive,Syndrome, Obstructive Sleep Apnea,syndrome, obstructive sleep apnea,Syndrome, Sleep Apnea, Obstructive,syndrome, sleep apnea, obstructive,Syndrome, Upper Airway Resistance, Sleep Apnea,syndrome, upper airway resistance, sleep apnea,Upper Airway Resistance Sleep Apnea Syndrome,upper airway resistance sleep apnea syndrome,Obstructive sleep apnea
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Preoperative Severe OSA patients
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Postoperative Severe OSA patients
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Patients who completed the collection of oral microbiota samples in tongue base (oropharynx site) after surgery one month after undergoing adeno-tonsillectomy
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V3-V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- Mann-Whitney (Wilcoxon)
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- unchanged
- Chao1 Abundance-based estimator of species richness
- unchanged
- Simpson Estimator of species richness and species evenness: more weight on species evenness
- unchanged
- Richness Number of species
- unchanged
Signature 1
Source: Figure 6F
Description: Species differentially abundant in the Preoperative Severe Obstructive Sleep Apnea (OSA) patient and Postoperative Severe Obstructive Sleep Apnea (OSA) patients.
Abundance in Group 1: increased abundance in Postoperative Severe OSA patients
| NCBI | Quality Control | Links |
|---|---|---|
| Porphyromonas | ||
| Treponema |
Revision editor(s): MyleeeA
Signature 2
Source: Figure 6F
Description: Species differentially abundant in the Preoperative Severe Obstructive Sleep Apnea (OSA) patient and Postoperative Severe Obstructive Sleep Apnea (OSA) patients.
Abundance in Group 1: decreased abundance in Postoperative Severe OSA patients
| NCBI | Quality Control | Links |
|---|---|---|
| Moraxella |
Revision editor(s): MyleeeA
