Visceral adiposity in postmenopausal women is associated with a pro-inflammatory gut microbiome and immunogenic metabolic endotoxemia/Experiment 1
From BugSigDB
Needs review
Subjects
- Location of subjects
- United States of America
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Visceral adipose tissue measurement Visceral adipose tissue measurement,visceral adipose tissue measurement
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Low Visceral Adiposity Tissue (VAT) group (Control/Unexposed group).
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- High Visceral Adiposity Tissue (VAT) group (Case/Exposed group)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- The high visceral adiposity tissue (VAT) group represents women with elevated visceral adipose tissue, which is associated with pro-inflammatory gut microbiome characteristics and metabolic endotoxemia
- Group 0 sample size Number of subjects in the control (unexposed) group
- 25
- Group 1 sample size Number of subjects in the case (exposed) group
- 25
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- 3 months
Lab analysis
- Sequencing type
- WMS
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- Not specified
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- Mann-Whitney (Wilcoxon)
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
- Matched on Factors on which subjects have been matched on in a case-control study
- age, sex
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- unchanged
- Chao1 Abundance-based estimator of species richness
- unchanged
Signature 1
Needs review
Source: Fig. 3E, Fig. 4b
Description: Differential abundant taxa between women with Low Visceral Adiposity Tissue and High Visceral Adiposity Tissue
Abundance in Group 1: increased abundance in High Visceral Adiposity Tissue (VAT) group (Case/Exposed group)
| NCBI | Quality Control | Links |
|---|---|---|
| Emergencia | ||
| Klebsiella | ||
| Parabacteroides | ||
| Parasutterella | ||
| Pseudomonadota | ||
| Shigella | ||
| uncultured Burkholderia sp. |
Revision editor(s): Vandana Maddi, KateRasheed
Signature 2
Reviewed Marked as Reviewed by ChiomaBlessing on 2024-11-28
Source: Fig. 4b
Description: Differential abundant taxa between women with Low Visceral Adiposity Tissue and High Visceral Adiposity Tissue
Abundance in Group 1: decreased abundance in High Visceral Adiposity Tissue (VAT) group (Case/Exposed group)
| NCBI | Quality Control | Links |
|---|---|---|
| Anaerostipes | ||
| Barnesiella | ||
| Desulfovibrio | ||
| Intestinimonas | ||
| Massiliimalia | ||
| Negativibacillus |
Revision editor(s): Vandana Maddi, KateRasheed
