Ketogenic Diets in Children With Intractable Epilepsy and its Effects on Gastrointestinal Function, Gut Microbiome, Inflammation, and Quality of Life/Experiment 1
From BugSigDB
Needs review
Subjects
- Location of subjects
- Australia
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Ketogenic diet Ketogenic diet,ketogenic diet
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- patients with intractable epilepsy (IE) controls
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- patients with intractable epilepsy (IE) on the ketogenic diet (KD)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- children between 0 and 17 diagnosed with intractable epilepsy (IE) by their treating neurologist and undergoing ketogenic diet (KD) treatment
- Group 0 sample size Number of subjects in the control (unexposed) group
- 12
- Group 1 sample size Number of subjects in the case (exposed) group
- 14
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- ANOSIM
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- unchanged
- Simpson Estimator of species richness and species evenness: more weight on species evenness
- unchanged
Signature 1
Needs review
Source: Supplemental Digital Content 4
Description: Comparison of IE group receiving ketogenic diet treatment vs IE control group undergoing traditional treatment
Abundance in Group 1: increased abundance in patients with intractable epilepsy (IE) on the ketogenic diet (KD)
| NCBI | Quality Control | Links |
|---|---|---|
| Bacteroidota |
Revision editor(s): Kavyaayala
Signature 2
Needs review
Source: Supplemental Digital Content 4
Description: Comparison of IE group receiving ketogenic diet treatment vs IE control group undergoing traditional treatment
Abundance in Group 1: decreased abundance in patients with intractable epilepsy (IE) on the ketogenic diet (KD)
| NCBI | Quality Control | Links |
|---|---|---|
| Actinomycetota |
Revision editor(s): Kavyaayala
