The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet
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Quality control
- Retracted paper
- Contamination issues suspected
- Batch effect issues suspected
- Uncontrolled confounding suspected
- Results are suspect (various reasons)
- Tags applied
Experiment 1
Subjects
- Location of subjects
- United States of America
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Mus musculus
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Response to ketogenic diet Response to ketogenic diet,response to ketogenic diet
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- control diet (CD) group
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- ketogenic diet (KD) group
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- specific-pathogen free (SPF) mice with 6 Hz induced seizures after 14 days of ketogenic diet treatment
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- Kruskall-Wallis
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- Matched on Factors on which subjects have been matched on in a case-control study
- age, sex
Signature 1
Source: Figure S1D
Description: Comparing fecal microbiome of KD group mice vs CD group mice after 14 days of treatment
Abundance in Group 1: increased abundance in ketogenic diet (KD) group
| NCBI | Quality Control | Links |
|---|---|---|
| Akkermansia muciniphila | ||
| Erysipelotrichaceae | ||
| Sutterella |
Revision editor(s): Kavyaayala
Signature 2
Source: Figure S1D
Description: Comparing fecal microbiome of KD group mice vs CD group mice after 14 days of treatment
Abundance in Group 1: decreased abundance in ketogenic diet (KD) group
| NCBI | Quality Control | Links |
|---|---|---|
| Allobaculum | ||
| Bifidobacterium | ||
| Desulfovibrio | ||
| Bifidobacterium longum |
Revision editor(s): Kavyaayala
Experiment 2
Subjects
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- specific-pathogen free (SPF) mice with 6 Hz induced seizures after 8 days of ketogenic diet treatment
Lab analysis
Statistical Analysis
Signature 1
Source: Figure S1D
Description: Comparing fecal microbiome of KD group mice vs CD group mice after 8 days of treatment
Abundance in Group 1: increased abundance in ketogenic diet (KD) group
| NCBI | Quality Control | Links |
|---|---|---|
| Akkermansia muciniphila | ||
| Parabacteroides | ||
| Erysipelotrichaceae |
Revision editor(s): Kavyaayala
Signature 2
Source: Figure S1D
Description: Comparing fecal microbiome of KD group mice vs CD group mice after 8 days of treatment
Abundance in Group 1: decreased abundance in ketogenic diet (KD) group
| NCBI | Quality Control | Links |
|---|---|---|
| Allobaculum | ||
| Bifidobacterium | ||
| Desulfovibrio | ||
| Bifidobacterium longum |
Revision editor(s): Kavyaayala
Experiment 3
Subjects
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- specific-pathogen free (SPF) mice with 6 Hz induced seizures after 4 days of ketogenic diet treatment
Lab analysis
Statistical Analysis
Signature 1
Source: Figure S1D
Description: Comparing fecal microbiome of KD group mice vs CD group mice after 4 days of treatment
Abundance in Group 1: increased abundance in ketogenic diet (KD) group
| NCBI | Quality Control | Links |
|---|---|---|
| Akkermansia muciniphila | ||
| Erysipelotrichaceae | ||
| Parabacteroides |
Revision editor(s): Kavyaayala
Signature 2
Source: Figure S1D
Description: Comparing fecal microbiome of KD group mice vs CD group mice after 4 days of treatment
Abundance in Group 1: decreased abundance in ketogenic diet (KD) group
| NCBI | Quality Control | Links |
|---|---|---|
| Desulfovibrio |
Revision editor(s): Kavyaayala
