The Microbiome of Prostate Fluid Is Associated With Prostate Cancer/Experiment 1
From BugSigDB
Reviewed Marked as Reviewed by Peace Sandy on 2024-1-29
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Prostate gland secretion Prostate fluid,Prostate secretion,Prostatic fluid,Secretion of prostate,Secretion of prostate gland,Prostate gland secretion,prostate gland secretion
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Prostate cancer cancer of prostate gland,hereditary prostate cancer,malignant neoplasm of prostate,malignant neoplasm of prostate gland,malignant neoplasm of the prostate,malignant prostate gland neoplasm,malignant prostate neoplasm,malignant prostate tumor,malignant tumor of prostate,malignant tumor of the prostate,NGP - new growth of prostate,prostate cancer,prostate cancer, familial,prostate gland cancer,prostate neoplasm,prostatic cancer,prostatic neoplasm,tumor of the prostate,Prostate cancer
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- non-prostate cancer
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- prostate cancer
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Prostate cancer commonest male malignant tumors determined by pathology of prostate biopsy
- Group 0 sample size Number of subjects in the control (unexposed) group
- 27
- Group 1 sample size Number of subjects in the case (exposed) group
- 32
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- 4 weeks
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V3-V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- Mann-Whitney (Wilcoxon)
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- decreased
- Simpson Estimator of species richness and species evenness: more weight on species evenness
- increased
- Richness Number of species
- unchanged
Signature 1
Reviewed Marked as Reviewed by Peace Sandy on 2024-1-29
Source: Figure 5
Description: Analysis of the specific microbial species differences. (A) The differences in microbial species between the two groups were explored.
Abundance in Group 1: increased abundance in prostate cancer
| NCBI | Quality Control | Links |
|---|---|---|
| Carnobacterium | ||
| Geobacillus | ||
| Lactococcus | ||
| Streptococcus |
Revision editor(s): WikiWorks, Peace Sandy
Signature 2
Reviewed Marked as Reviewed by Peace Sandy on 2024-1-29
Source: Figure 5
Description: Analysis of the specific microbial species differences. (A) The differences in microbial species between the two groups were explored.
Abundance in Group 1: decreased abundance in prostate cancer
| NCBI | Quality Control | Links |
|---|---|---|
| Alkaliphilus | ||
| Cronobacter | ||
| Enterococcus | ||
| Paenibacillus |
Revision editor(s): WikiWorks, Peace Sandy
