Shift in skin microbiota of Western European women across aging/Experiment 1
From BugSigDB
Subjects
- Location of subjects
- France
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Skin of body Entire integument,Entire skin,Integument,Integumental organ,Pelt,Skin,Skin organ,Skin of body,skin of body
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Age Age,age
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- younger age
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- older age European women
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- aging
- Group 0 sample size Number of subjects in the control (unexposed) group
- 17
- Group 1 sample size Number of subjects in the case (exposed) group
- 17
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- 1 month
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V3-V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- LEfSe
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
- LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
- 3
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- increased
- Chao1 Abundance-based estimator of species richness
- unchanged
- Richness Number of species
- unchanged
Signature 1
Needs review
Source: Figure 4, Figure S1, Figure s2
Description: Taxonomic analysis of forehead microbiota using LEfSe between older and younger european women
Abundance in Group 1: increased abundance in older age European women
| NCBI | Quality Control | Links |
|---|---|---|
| Arthrobacter | ||
| Sneathia | ||
| Moraxellaceae | ||
| Pseudomonadales | ||
| Corynebacterium | ||
| Halomonadaceae | ||
| Halomonas | ||
| Oceanospirillales | ||
| Neisseriaceae | ||
| Neisseriales | ||
| Betaproteobacteria | ||
| Pseudomonadota |
Revision editor(s): WikiWorks
Signature 2
Needs review
Source: Figure 4, Figure S1, Figure s2
Description: Taxonomic analysis of forehead microbiota using LEfSe between older and younger european women
Abundance in Group 1: decreased abundance in older age European women
| NCBI | Quality Control | Links |
|---|---|---|
| Propionibacteriaceae | ||
| Propionibacterium | ||
| Propionibacteriales |
Revision editor(s): WikiWorks
