Disrupted tongue microbiota and detection of nonindigenous bacteria on the day of allogeneic hematopoietic stem cell transplantation/Experiment 1
From BugSigDB
Reviewed Marked as Reviewed by Claregrieve1 on 2022/09/1
Subjects
- Location of subjects
- Japan
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Tongue Glossus,Tongue,tongue
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Response to allogeneic hematopoietic stem cell transplant Response to allogeneic hematopoietic stem cell transplant,response to allogeneic hematopoietic stem cell transplant
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- community-dwelling controls
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- allogeneic-hematopoietic stem cell transplant
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- patient ages 36-69 years old undergoing allogeneic- hematopoietic stem cell transplantation
- Group 0 sample size Number of subjects in the control (unexposed) group
- 164
- Group 1 sample size Number of subjects in the case (exposed) group
- 45
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V1-V2
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Ion Torrent
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- Mann-Whitney (Wilcoxon)
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
- Matched on Factors on which subjects have been matched on in a case-control study
- age
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- decreased
- Richness Number of species
- decreased
Signature 2
Reviewed Marked as Reviewed by Claregrieve1 on 2022/09/1
Source: Fig. 2
Description: Differential abundances of predominant bacterial genera in the tongue microbiota of community-dwelling adults and allogeneic-hematopoietic stem cell transplantation patients
Abundance in Group 1: decreased abundance in allogeneic-hematopoietic stem cell transplant
| NCBI | Quality Control | Links |
|---|---|---|
| Alloprevotella | ||
| Haemophilus | ||
| Leptotrichia | ||
| Neisseria | ||
| Oribacterium | ||
| Prevotella | ||
| Streptococcus |
Revision editor(s): Claregrieve1, WikiWorks
