The gut microbiota is associated with psychiatric symptom severity and treatment outcome among individuals with serious mental illness/Experiment 3

From BugSigDB


Reviewed Marked as Reviewed by ChiomaBlessing on 2024-2-20

Curated date: 2021/01/10

Curator: WikiWorks

Revision editor(s): WikiWorks, ChiomaBlessing

Subjects

Location of subjects
United States of America
Host species Species from which microbiome was sampled. Contact us to have more species added.
Homo sapiens
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Anxiety disorder anxiety,anxiety disorder,anxiety disorders,anxiety neuroses,anxiety neurosis,anxiety state,anxiety/mood disorders,chronic stress,mood and anxiety disorder,mood and anxiety disorders,neurotic anxiety states,Anxiety disorder
Group 0 name Corresponds to the control (unexposed) group for case-control studies
mild anxiety
Group 1 name Corresponds to the case (exposed) group for case-control studies
severe anxiety
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
Patients in this group were diagnosed with severe anxiety (The primary patient-reported outcome measures used in this study were the Patient Health Questionnaire – 9 (PHQ-9) and the Patient Health Questionnaire – Generalized Anxiety Disorder screener (GAD-7); they were used to quantify anxiety severity).
Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
None

Lab analysis

Sequencing type
16S
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
V4
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
Illumina

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
relative abundances
Statistical test
LEfSe
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
No
LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
2


Signature 1

Reviewed Marked as Reviewed by ChiomaBlessing on 2024-2-20

Curated date: 2021/01/10

Curator: Fatima Zohra

Revision editor(s): WikiWorks, Atrayees, ChiomaBlessing

Source: Figure 1C and 1D

Description: Significant bacterial biomarkers among individuals with severe anxiety VS individuals with mild anxiety at admission

Abundance in Group 1: increased abundance in severe anxiety

NCBI Quality ControlLinks
Streptococcus anginosus
Lachnospiraceae bacterium 1_4_56FAA

Revision editor(s): WikiWorks, Atrayees, ChiomaBlessing

Signature 2

Reviewed Marked as Reviewed by ChiomaBlessing on 2024-2-20

Curated date: 2021/01/10

Curator: Fatima Zohra

Revision editor(s): WikiWorks, Merit, ChiomaBlessing

Source: Figure 1C and 1D

Description: Significant bacterial biomarkers among individuals with severe anxiety VS individuals with mild anxiety at admission

Abundance in Group 1: decreased abundance in severe anxiety

NCBI Quality ControlLinks
Actinomycetes
Actinomycetota
Agathobacter rectalis
Alistipes putredinis
Bacillota
Bifidobacterium adolescentis
Clostridia
Coprococcus catus
Corynebacteriaceae
Eubacteriales
Eubacterium ventriosum
Lawsonella
Mycobacteriales
Roseburia hominis
Roseburia inulinivorans
Ruminococcus sp.
Ruminococcaceae_UCG-010Ruminococcaceae_UCG-010

Revision editor(s): WikiWorks, Merit, ChiomaBlessing