Cervical microbiota in women with cervical intra-epithelial neoplasia, prior to and after local excisional treatment, a Norwegian cohort study/Experiment 1

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Reviewed Marked as Reviewed by Claregrieve1 on 2022/07/28

Curated date: 2021/01/10

Curator: WikiWorks

Revision editor(s): Claregrieve1, WikiWorks

Subjects

Location of subjects
Norway
Host species Species from which microbiome was sampled. Contact us to have more species added.
Homo sapiens
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Endocervix Endocervix,endocervix
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Cervical glandular intraepithelial neoplasia Cervical glandular intraepithelial neoplasia,cervical glandular intraepithelial neoplasia
Group 0 name Corresponds to the control (unexposed) group for case-control studies
normal
Group 1 name Corresponds to the case (exposed) group for case-control studies
LEEP group before procedure
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
women with suspected high grade cervical dysplasia planning for their first Loop Electrosurgical Excision Procedure
Group 0 sample size Number of subjects in the control (unexposed) group
100
Group 1 sample size Number of subjects in the case (exposed) group
89
Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
long-term antibiotic use

Lab analysis

Sequencing type
16S
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
Not specified
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
RT-qPCR

Statistical Analysis

Statistical test
Fisher's Exact Test
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
No


Signature 1

Reviewed Marked as Reviewed by Claregrieve1 on 2022/07/28

Curated date: 2021/01/10

Curator: Cynthia Anderson

Revision editor(s): Claregrieve1, WikiWorks

Source: Table 5

Description: Differential abundance of cervical microbiota in the LEEP group and the Reference group

Abundance in Group 1: increased abundance in LEEP group before procedure

NCBI Quality ControlLinks
Gardnerella vaginalis
Ureaplasma parvum
Metamycoplasma hominis

Revision editor(s): Claregrieve1, WikiWorks