Probiotics Ameliorate Colon Epithelial Injury Induced by Ambient Ultrafine Particles Exposure/Experiment 1
From BugSigDB
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Mus musculus
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Colon Hindgut,Large bowel,Posterior intestine,Colon,colon
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Air pollution air pollution,Air pollution
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- mice exposed to FRA
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Diesel exhaust particle (DEP) exposed mice
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- mice exposed to Diesel exhaust particles (DEP)
- Group 0 sample size Number of subjects in the control (unexposed) group
- 30
- Group 1 sample size Number of subjects in the case (exposed) group
- 37
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V3-V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- LEfSe
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
- LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
- 4
Signature 1
Needs review
Source: Figure 2C & text
Description: LEfSe histogram of fecal microbiota profiling from DEPs group (fecal samples from male n = 20 and female n = 17) and FRA group (fecal samples from male n = 15 and female n = 15) following 7‐day exposure.
Abundance in Group 1: increased abundance in Diesel exhaust particle (DEP) exposed mice
| NCBI | Quality Control | Links |
|---|---|---|
| Bacilli | ||
| Lactobacillales | ||
| Lactobacillus |
Revision editor(s): WikiWorks
Signature 2
Needs review
Source: Figure 2C & text
Description: LEfSe histogram of fecal microbiota profiling from DEPs group (fecal samples from male n = 20 and female n = 17) and FRA group (fecal samples from male n = 15 and female n = 15) following 7‐day exposure.
Abundance in Group 1: decreased abundance in Diesel exhaust particle (DEP) exposed mice
| NCBI | Quality Control | Links |
|---|---|---|
| Bacillota | ||
| Bacteroidaceae | ||
| Bacteroides | ||
| Clostridia | ||
| Eubacteriales | ||
| Lachnospiraceae | ||
| Clostridiaceae | ||
| Clostridiales bacterium | ||
| Clostridium | ||
| Clostridium sp. | ||
| Bacteroidales |
