Alterations of Gut Microbiota in Cholestatic Infants and Their Correlation With Hepatic Function/Experiment 1
From BugSigDB
Reviewed Marked as Reviewed by Shaimaa Elsafoury on 2021/02/09
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Extrahepatic cholestasis cholestasis of extrahepatic bile duct,Cholestasis, Extrahepatic,extrahepatic bile duct cholestasis,extrahepatic biliary Stasis,extrahepatic biliary stasis,extrahepatic cholestasis,extrahepatic cholestasis (finding),extrahepatic obstructive biliary disease,extrahepatic obstructive biliary disease (disorder),Extrahepatic cholestasis
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- healthy infants
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- cholestasis infants
- Group 0 sample size Number of subjects in the control (unexposed) group
- 37
- Group 1 sample size Number of subjects in the case (exposed) group
- 43
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- 4 weeks
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V3-V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- Mann-Whitney (Wilcoxon)
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- decreased
Signature 1
Reviewed Marked as Reviewed by Shaimaa Elsafoury on 2021/02/09
Source: Figure 2+ text
Description: Differentially abundundant gut microbiota in cholestatic infants vs healthy infants
Abundance in Group 1: increased abundance in cholestasis infants
| NCBI | Quality Control | Links |
|---|---|---|
| Streptococcus | ||
| Enterococcus | ||
| Staphylococcus | ||
| Megasphaera | ||
| Phyllobacterium | ||
| Megamonas |
Revision editor(s): WikiWorks
Signature 2
Reviewed Marked as Reviewed by Shaimaa Elsafoury on 2021/02/09
Source: Figure 2 + text
Description: Differentially abundundant gut microbiota in cholestatic infants vs healthy infants
Abundance in Group 1: decreased abundance in cholestasis infants
| NCBI | Quality Control | Links |
|---|---|---|
| Bifidobacterium | ||
| Bacteroides | ||
| Blautia | ||
| Faecalibacterium | ||
| Roseburia | ||
| Anaerostipes | ||
| Collinsella |
Revision editor(s): WikiWorks
