Distinct Features of Gut Microbiota in High-Altitude Tibetan and Middle-Altitude Han Hypertensive Patients/Experiment 1

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Reviewed Marked as Reviewed by Fatima on 2021/07/28

Curated date: 2021/02/17

Curator: Manuela

Revision editor(s): WikiWorks, Fatima, Rimsha, Manuela

Subjects

Location of subjects
China
Host species Species from which microbiome was sampled. Contact us to have more species added.
Homo sapiens
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Hypertension (hypertensive disease) or (hypertension),[X]Hypertensive diseases,[X]Hypertensive diseases (disorder),Blood Pressure, High,blood pressure, high,blood pressure, increased,Blood Pressures, High,High Blood Pressure,high blood pressure,High blood pressure (& [essential hypertension]),High Blood Pressures,HTN,HTN - hypertension,hyperpiesia,hypertension,hypertension NOS,HYPERTENSIVE DISEASE,hypertensive disease,Hypertensive disease (disorder),hypertensive disease NOS,Hypertensive disease NOS (disorder),hypertensive disorder,increased blood pressure,pressure, high blood,SURG COMP - HYPERTENSION,vascular hypertensive disorder,Hypertension
Group 0 name Corresponds to the control (unexposed) group for case-control studies
Han Hypertensive at Low Altitude (LHH)
Group 1 name Corresponds to the case (exposed) group for case-control studies
Tibetan Hypertensive at High Altitude (HTH)
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
Tibetan participants with hypertension living at high altitudes.
Group 0 sample size Number of subjects in the control (unexposed) group
34
Group 1 sample size Number of subjects in the case (exposed) group
38
Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
3 months

Lab analysis

Sequencing type
16S
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
V3-V4
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
Illumina

Statistical Analysis

Statistical test
T-Test
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
No
Matched on Factors on which subjects have been matched on in a case-control study
age, sex

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
increased

Signature 1

Reviewed Marked as Reviewed by Lwaldron on 2021/02/18

Curated date: 2021/02/17

Curator: Manuela

Revision editor(s): Manuela

Source: Figure 2c

Description:

Abundance in Group 1: decreased abundance in Tibetan Hypertensive at High Altitude (HTH)

NCBI Quality ControlLinks
Bacillota

Revision editor(s): Manuela

Signature 2

Reviewed Marked as Reviewed by Lwaldron on 2021/02/18

Curated date: 2021/02/17

Curator: Manuela

Revision editor(s): Manuela

Source: Figure 2c

Description:

Abundance in Group 1: increased abundance in Tibetan Hypertensive at High Altitude (HTH)

NCBI Quality ControlLinks
Bacteroidota
Verrucomicrobiota

Revision editor(s): Manuela