Association of high-risk human papillomavirus infection duration and cervical lesions with vaginal microbiota composition/Experiment 1
From BugSigDB
Reviewed Marked as Reviewed by Fatima on 2022/04/6
Curated date: 2021/03/18
Curator: Cynthia Anderson
Revision editor(s): WikiWorks, Fatima, Cynthia Anderson, Peace Sandy
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Vagina Vagina,vagina,Distal oviductal region,Distal portion of oviduct,Vaginae
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Cervical glandular intraepithelial neoplasia Cervical glandular intraepithelial neoplasia,cervical glandular intraepithelial neoplasia
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- persistent HPV+ with LSIL
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- persistent HPV+ with HSIL
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- persistent HPV+ infection ( same HPV subtype has infected for >12 months) with high grade squamus intraepithelial lesion
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- Not specified
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- raw counts
- Statistical test
- ANOVA
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
Signature 1
Reviewed Marked as Reviewed by Fatima on 2022/04/6
Source: Figure 3A
Description: Differential florae types in the comparison of the microbiota between high-risk human papillomavirus (HPV) persistent infection higher-grade squamous intraepithelial lesion (HSIL) and the high-risk HPV persistent infection with lower-grade squamous intraepithelial lesion (LSIL) group
Abundance in Group 1: decreased abundance in persistent HPV+ with HSIL
Revision editor(s): Fatima, Cynthia Anderson
