Association of high-risk human papillomavirus infection duration and cervical lesions with vaginal microbiota composition/Experiment 5

Reviewed Marked as Reviewed by Fatima on 2022/04/6

Curated date: 2021/03/19

Curator: Cynthia Anderson

Revision editor(s): Cynthia Anderson, WikiWorks

Subjects

Location of subjects: China

Host species Species from which microbiome was sampled. Contact us to have more species added.: Homo sapiens

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology: Vagina Vagina,vagina,Distal oviductal region,Distal portion of oviduct,Vaginae

Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology: Cervical glandular intraepithelial neoplasia Cervical glandular intraepithelial neoplasia,cervical glandular intraepithelial neoplasia

Group 0 name Corresponds to the control (unexposed) group for case-control studies: persistent HPV+ with LSIL

Group 1 name Corresponds to the case (exposed) group for case-control studies: persistent HPV+ with HSIL

Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group: persistent HPV+ infection ( same HPV subtype has infected for >12 months) with high grade squamus intraepithelial lesion

Lab analysis

Sequencing type: 16S

16S variable region One or more hypervariable region(s) of the bacterial 16S gene: Not specified

Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance: Illumina

Statistical Analysis

Statistical test: LEfSe

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Reviewed Marked as Reviewed by Fatima on 2022/04/6

Curated date: 2021/03/19

Curator: Cynthia Anderson

Revision editor(s): Cynthia Anderson

Source: Figure 4A

Description: Abundance analysis of the microbiota between high-risk human papillomavirus (HPV) persistent infection with higher-grade squamous intraepithelial lesion (HSIL) and the high-risk HPV persistent infection with lower-grade squamous intraepithelial lesion (LSIL) group

Abundance in Group 1: increased abundance in persistent HPV+ with HSIL

NCBI	Quality Control	Links
Streptococcus agalactiae

Revision editor(s): Cynthia Anderson

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Reviewed Marked as Reviewed by Fatima on 2022/04/6

Curated date: 2021/03/19

Curator: Cynthia Anderson

Revision editor(s): Cynthia Anderson

Source: Figure 4A

Description: Abundance analysis of the microbiota between high-risk human papillomavirus (HPV) persistent infection with higher-grade squamous intraepithelial lesion (HSIL) and the high-risk HPV persistent infection with lower-grade squamous intraepithelial lesion (LSIL) group

Abundance in Group 1: decreased abundance in persistent HPV+ with HSIL

NCBI	Quality Control	Links
Faecalibacterium
Planococcaceae
Corynebacterium tuberculostearicum
Lawsonella
Erysipelotrichales
Micrococcaceae
Pseudarthrobacter oxydans
Corynebacterium aurimucosum
Peptoniphilus
Actinomycetaceae
Anaerococcus
[Ruminococcus] torques
Prevotella disiens
Nocardiaceae
Dialister
Deinococcota
Actinomycetales
Prevotella
Gardnerella
Deinococci
Leuconostoc
Nitrosomonadaceae
Xanthomonadales
Howardella
Finegoldia
Peptoniphilus coxii
Bifidobacterium dentium
Staphylococcus
Staphylococcus aureus
Staphylococcaceae
Bacillales
Enterococcus durans
Enterococcus
Enterococcaceae
Ligilactobacillus salivarius
Dialister micraerophilus
Selenomonadales
Negativicutes
Bifidobacteriaceae
Bifidobacteriales
Streptococcaceae

Revision editor(s): Cynthia Anderson