Changes of vaginal microbiota during cervical carcinogenesis in women with human papillomavirus infection/Experiment 1
From BugSigDB
Reviewed Marked as Reviewed by Claregrieve1 on 2022/10/6
Curated date: 2021/03/21
Curator: Cynthia Anderson
Revision editor(s): WikiWorks, LGeistlinger, Cynthia Anderson, Claregrieve1
Subjects
- Location of subjects
- South Korea
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Vaginal fluid Vaginal discharge,Vaginal secretion,Vaginal fluid,vaginal fluid
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Cervical glandular intraepithelial neoplasia Cervical glandular intraepithelial neoplasia,cervical glandular intraepithelial neoplasia
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- healthy controls
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- CIN2+/cervical cancer
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- patients with cervical intraepithelial neoplasia 2+ or cervical cancer confirmed by biopsy
- Group 0 sample size Number of subjects in the control (unexposed) group
- 10
- Group 1 sample size Number of subjects in the case (exposed) group
- 20
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V3-V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Statistical test
- Chi-Square
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- unchanged
Signature 1
Reviewed Marked as Reviewed by Claregrieve1 on 2022/10/6
Curated date: 2021/03/21
Curator: Cynthia Anderson
Revision editor(s): Cynthia Anderson, Claregrieve1
Source: Table 2
Description: Differential microbial abundance between healthy controls and patients with cervical disease with CIN 2 or 3 and cervical cancer
Abundance in Group 1: increased abundance in CIN2+/cervical cancer
| NCBI | Quality Control | Links |
|---|---|---|
| Dialister invisus | ||
| Fannyhessea vaginae | ||
| Finegoldia magna | ||
| Gardnerella vaginalis | ||
| Hoylesella buccalis | ||
| Hoylesella timonensis |
Revision editor(s): Cynthia Anderson, Claregrieve1
