Decreased dietary fiber intake and structural alteration of gut microbiota in patients with advanced colorectal adenoma/Experiment 1
From BugSigDB
Needs review
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Colorectal adenoma adenoma of large bowel,adenoma of large intestine,adenoma of the large bowel,adenoma of the large intestine,colorectal adenoma,colorectum adenoma,large bowel adenoma,large intestine adenoma,Colorectal adenoma
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Healthy control group (HC)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Advanced colorectal adenoma group (A-CRA)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Patients with a diagnosis of A-CRA by pathological examination were enrolled in the A-CRA group.
- Group 0 sample size Number of subjects in the control (unexposed) group
- 47
- Group 1 sample size Number of subjects in the case (exposed) group
- 47
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- 6 months None of the patients had received systemic or oral topical corticosteroids, antibiotics, aspirin, other nonsteroidal antiinflammatory drugs (16), or health products that regulate intestinal microbiota within 6 mo before enrollment
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V1-V3
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Roche454
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- Mann-Whitney (Wilcoxon)
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- Matched on Factors on which subjects have been matched on in a case-control study
- age, sex
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- unchanged
- Chao1 Abundance-based estimator of species richness
- unchanged
Signature 1
Reviewed Marked as Reviewed by Rimsha on 2022/05/4
Source: Table 4
Description: Significant differences in some genera identified between the HC (n = 47) and A-CRA (n = 47) groups
Abundance in Group 1: increased abundance in Advanced colorectal adenoma group (A-CRA)
| NCBI | Quality Control | Links |
|---|---|---|
| Bacteroides | ||
| Streptococcus | ||
| Enterococcus |
Signature 2
Reviewed Marked as Reviewed by Rimsha on 2022/05/4
Source: Table 4
Description: Significant differences in some genera identified between the HC (n = 47) and A-CRA (n = 47) groups
Abundance in Group 1: decreased abundance in Advanced colorectal adenoma group (A-CRA)
| NCBI | Quality Control | Links |
|---|---|---|
| Eubacterium | ||
| Roseburia | ||
| Clostridium |
Revision editor(s): Aleru Divine
