Microbiota profile is different for early and invasive colorectal cancer and is consistent throughout the colon/Experiment 1
From BugSigDB
Reviewed Marked as Reviewed by Fatima on 2022/07/6
Subjects
- Location of subjects
- Japan
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Colon Hindgut,Large bowel,Posterior intestine,Colon,colon
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Colorectal cancer cancer of colorectum,cancer of large bowel,cancer of large intestine,cancer of the large bowel,colon cancer,colorectal cancer,colorectum cancer,CRC,large intestine cancer,malignant colorectal neoplasm,malignant colorectal tumor,malignant colorectum neoplasm,malignant large bowel neoplasm,malignant large bowel tumor,malignant large intestine neoplasm,malignant large intestine tumor,malignant neoplasm of colorectum,malignant neoplasm of large bowel,malignant neoplasm of large intestine,malignant neoplasm of the large bowel,malignant neoplasm of the large intestine,malignant tumor of large bowel,malignant tumor of large intestine,malignant tumor of the large bowel,malignant tumor of the large intestine,Colorectal cancer
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Early cancer group
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Invasive cancer group
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Patients undergoing ESD procedure for colorectal cancer
- Group 0 sample size Number of subjects in the control (unexposed) group
- 11
- Group 1 sample size Number of subjects in the case (exposed) group
- 14
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V3-V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Statistical test
- Welch's T-Test
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
Signature 1
Reviewed Marked as Reviewed by Fatima on 2022/07/18
Source: Figure 1, Figure 5, Figure 4
Description: Figure 1: Fusobacterium genera profile for invasive (YES) and early (NO) colorectal cancer.
Abundance in Group 1: increased abundance in Invasive cancer group
| NCBI | Quality Control | Links |
|---|---|---|
| Fusobacterium | ||
| Fusobacterium vincentii | ||
| Fusobacterium sp. |
Signature 2
Reviewed Marked as Reviewed by Fatima on 2022/07/18
Source: Figure 2, Figure 3
Description: Oribacterium parvum profile for invasive (YES) and early (NO) colorectal cancer (colon samples).
Abundance in Group 1: decreased abundance in Invasive cancer group
| NCBI | Quality Control | Links |
|---|---|---|
| Oribacterium parvum | ||
| Clostridiales bacterium |
