Factors Associated With the Microbiome in Moderate-Late Preterm Babies: A Cohort Study From the DIAMOND Randomized Controlled Trial/Experiment 17

From BugSigDB


Needs review

Curated date: 2024/03/31

Curator: MyleeeA

Revision editor(s): MyleeeA

Subjects

Location of subjects
New Zealand
Host species Species from which microbiome was sampled. Contact us to have more species added.
Homo sapiens
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Spontaneous preterm birth Spontaneous preterm birth,spontaneous preterm birth
Group 0 name Corresponds to the control (unexposed) group for case-control studies
Mixed Feeding (4M)
Group 1 name Corresponds to the case (exposed) group for case-control studies
Breast Milk (4M)
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
Moderate–late preterm (MLPT) babies at 4-months corrected age who were breastmilk fed
Group 0 sample size Number of subjects in the control (unexposed) group
95
Group 1 sample size Number of subjects in the case (exposed) group
36
Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
N/A

Lab analysis

Sequencing type
WMS
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
Not specified
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
Illumina

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
relative abundances
Statistical test
MaAsLin2
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
Yes

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
decreased

Signature 1

Needs review

Curated date: 2024/03/31

Curator: MyleeeA

Revision editor(s): MyleeeA

Source: Supplementary Table S4

Description: Linear modelling results showing taxa associated with factors at 4-month corrected age, measured by shotgun metagenomics data.

Abundance in Group 1: increased abundance in Breast Milk (4M)

NCBI Quality ControlLinks
unclassified Bilophila

Revision editor(s): MyleeeA