Factors Associated With the Microbiome in Moderate-Late Preterm Babies: A Cohort Study From the DIAMOND Randomized Controlled Trial/Experiment 18

From BugSigDB


Needs review

Curated date: 2024/03/31

Curator: MyleeeA

Revision editor(s): MyleeeA

Subjects

Location of subjects
New Zealand
Host species Species from which microbiome was sampled. Contact us to have more species added.
Homo sapiens
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Spontaneous preterm birth Spontaneous preterm birth,spontaneous preterm birth
Group 0 name Corresponds to the control (unexposed) group for case-control studies
Mixed Feeding (D10)
Group 1 name Corresponds to the case (exposed) group for case-control studies
Only Formula (D10)
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
Moderate–late preterm (MLPT) babies at Day 10 who were fed with only formula
Group 0 sample size Number of subjects in the control (unexposed) group
95
Group 1 sample size Number of subjects in the case (exposed) group
42
Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
N/A

Lab analysis

Sequencing type
16S
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
V3-V4
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
Illumina

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
relative abundances
Statistical test
MaAsLin2
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
Yes

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
increased

Signature 1

Needs review

Curated date: 2024/03/31

Curator: MyleeeA

Revision editor(s): MyleeeA

Source: Supplementary Table S4

Description: Linear modelling results showing taxa associated with different factors at day10, measured by 16S amplicon data.

Abundance in Group 1: increased abundance in Only Formula (D10)

NCBI Quality ControlLinks
Bifidobacterium

Revision editor(s): MyleeeA