Oral status in patients with early rheumatoid arthritis: a prospective, case-control study/Experiment 1
Curated date: 2022/11/02
Curator: Tislam
Revision editor(s): WikiWorks, Tislam, Atrayees, Peace Sandy
Subjects
- Location of subjects
- Germany
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Subgingival dental plaque Subgingival plaque,Subgingival dental plaque,subgingival dental plaque
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Rheumatoid arthritis Arthritis or polyarthritis, rheumatic,arthritis or polyarthritis, rheumatic,Arthritis, Rheumatoid,arthritis, rheumatoid,atrophic Arthritis,atrophic arthritis,autoimmune arthritis,Chronic rheumatic arthritis,Proliferative arthritis,RA,RA - Rheumatoid arthritis,RhA - Rheumatoid arthritis,Rheumatic gout,rheumatoid arthritis,Rheumatoid arthritis (disorder),Rheumatoid arthritis NOS,Rheumatoid arthritis NOS (disorder),rheumatoid arthritis, susceptibility to,Rheumatoid disease,Rheumatoid arthritis
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Healthy Controls
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Early Rheumatoid Arthritis
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Patients with Early Rheumatoid Arthritis
- Group 0 sample size Number of subjects in the control (unexposed) group
- 22
- Group 1 sample size Number of subjects in the case (exposed) group
- 22
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- Intake of antibiotics during the past 6 months
Lab analysis
- Sequencing type
- PCR
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- Not specified
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- RT-qPCR
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- Mann-Whitney (Wilcoxon)
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
Signature 1
Source: Table 3, Table 4, Text
Description: Microbiological data and quantitative real-time PCR measurements of abundance of subgingival microbiota in ERA patients and controls.
Microbiological data and quantitative real-time PCR measurements of abundance of supragingival microbiota in ERA patients and controls
Abundance in Group 1: increased abundance in Early Rheumatoid Arthritis
| NCBI | Quality Control | Links |
|---|---|---|
| Tannerella forsythia | ||
| Streptococcus anginosus |
Revision editor(s): Tislam, Atrayees, Peace Sandy
Signature 2
Source: Table 3, Table 4, Text
Description: Microbiological data and quantitative real-time PCR measurements of abundance of subgingival microbiota in ERA patients and controls
Microbiological data and quantitative real-time PCR measurements of abundance of supragingival microbiota in ERA patients and controls
Abundance in Group 1: decreased abundance in Early Rheumatoid Arthritis
| NCBI | Quality Control | Links |
|---|---|---|
| Actinomyces sp. | ||
| Corynebacterium durum | ||
| Fusobacteriota | ||
| Lactobacillus gasseri | ||
| Leptotrichia sp. | ||
| Rothia dentocariosa | ||
| Streptococcus gordonii | ||
| Lactobacillus |
Revision editor(s): Tislam, Peace Sandy
