Role of a probiotic strain in the modulation of gut microbiota and cytokines in inflammatory bowel disease/Experiment 1
Curated date: 2023/03/11
Curator: Brian
Revision editor(s): Brian, Atrayees, Aiyshaaaa, Peace Sandy, ChiomaBlessing, Folakunmi
Subjects
- Location of subjects
- India
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Treatment Treatment,treatment
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Placebo group before intervention/treatment
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Bacillus clausii UBBC-07 group after intervention/treatment
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Patients who were treated with Bacillus clausii UBBC-07 and evaluated after treatment/intervention for the effect of the probiotic on gut microbiota. Patients were of either sex, clinically diagnosed with Ulcerative Colitis or Crohn's Disease, and between 18 and 60 years.
- Group 0 sample size Number of subjects in the control (unexposed) group
- 54
- Group 1 sample size Number of subjects in the case (exposed) group
- 54
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V3-V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- Kruskall-Wallis
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.01
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
Signature 1
Source: Results within text: Page 4, under subheading "Metagenomic analysis"
Description: Differentially abundant taxa in the UC patients of the Bacillus clausii UBBC-07 group post intervention/ treatment compared to placebo groups post intervention/ treatment
Abundance in Group 1: increased abundance in Bacillus clausii UBBC-07 group after intervention/treatment
| NCBI | Quality Control | Links |
|---|---|---|
| Bacilli | ||
| Bacillota | ||
| Erysipelotrichales | ||
| Faecalibacterium | ||
| Lactobacillales | ||
| Lactobacillus | ||
| Bifidobacterium |
Revision editor(s): Folakunmi, ChiomaBlessing
Signature 2
Source: Results within text: Page 4, under subheading "Metagenomic analysis."
Description: Differentially abundant taxa in the UC patients of the Bacillus clausii UBBC-07 group post intervention/ treatment compared to placebo groups post intervention/ treatment
Abundance in Group 1: decreased abundance in Bacillus clausii UBBC-07 group after intervention/treatment
| NCBI | Quality Control | Links |
|---|---|---|
| Bacteroidia | ||
| Selenomonadales |
Revision editor(s): Folakunmi, ChiomaBlessing
