Urinary Microbiome and Psychological Factors in Women with Overactive Bladder/Experiment 1
From BugSigDB
Reviewed Marked as Reviewed by Folakunmi on 2024-1-18
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Female urethra Urethra feminina,Urethra muliebris,Female urethra,female urethra
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Overactive bladder Hypertonic bladder,overactive bladder,overactive bladder (disease),Overactive Detrusor,Urinary Bladder Overactive,Overactive bladder
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Asymptomatic controls
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Overactive Bladder (OAB) patients
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Adult patients aged 18 or above, diagnosed with OAB
- Group 0 sample size Number of subjects in the control (unexposed) group
- 25
- Group 1 sample size Number of subjects in the case (exposed) group
- 30
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- LEfSe
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
- LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
- 2.5
Alpha Diversity
- Chao1 Abundance-based estimator of species richness
- decreased
- Simpson Estimator of species richness and species evenness: more weight on species evenness
- decreased
Signature 1
Reviewed Marked as Reviewed by Folakunmi on 2024-1-18
Source: Figure 4
Description: Urinary microbiomes that were significantly more increased in the samples of female patients with OAB (Over Active Bladder) compared to the control samples from asymptomatic women
Abundance in Group 1: increased abundance in Overactive Bladder (OAB) patients
| NCBI | Quality Control | Links |
|---|---|---|
| Staphylococcus | ||
| Sneathia | ||
| Proteus | ||
| Helcococcus | ||
| Gemella | ||
| Mycoplasma | ||
| Aerococcus |
Revision editor(s): Ojotuleonalo
Signature 2
Reviewed Marked as Reviewed by Folakunmi on 2024-1-18
Source: Figure 4
Description: Urinary microbiomes that were significantly more decreased in the samples of female patients with OAB (Over Active Bladder) compared to the control samples from asymptomatic women
Abundance in Group 1: decreased abundance in Overactive Bladder (OAB) patients
| NCBI | Quality Control | Links |
|---|---|---|
| Anaerococcus | ||
| Campylobacter | ||
| Dialister | ||
| Enterococcus | ||
| Finegoldia | ||
| Fusobacterium | ||
| Jonquetella | ||
| Lactobacillus | ||
| Lactococcus | ||
| Novosphingobium | ||
| Prevotella | ||
| Pyramidobacter | ||
| Ureaplasma |
Revision editor(s): Ojotuleonalo
