Urinary Microbiome and Psychological Factors in Women with Overactive Bladder/Experiment 2
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Female urethra Urethra feminina,Urethra muliebris,Female urethra,female urethra
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Anxiety Anxiety,anxiety
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Overactive Bladder (OAB) without anxiety
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Overactive Bladder (OAB) with anxiety
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Adult patients aged 18 or above, diagnosed with OAB and have anxiety
- Group 0 sample size Number of subjects in the control (unexposed) group
- 18
- Group 1 sample size Number of subjects in the case (exposed) group
- 12
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- LEfSe
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
- LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
- 2.5
Alpha Diversity
- Pielou Quantifies how equal the community is numerically
- increased
- Shannon Estimator of species richness and species evenness: more weight on species richness
- increased
- Chao1 Abundance-based estimator of species richness
- increased
- Simpson Estimator of species richness and species evenness: more weight on species evenness
- increased
Signature 1
Curated date: 2023/10/08
Curator: Ojotuleonalo
Revision editor(s): Ojotuleonalo, Peace Sandy, Folakunmi
Source: Figure 5C
Description: Urinary microbiomes that were significantly more increased in the samples of female patients with OAB (Over Active Bladder) with anxiety compared to the samples of female patients with OAB without anxiety
Abundance in Group 1: increased abundance in Overactive Bladder (OAB) with anxiety
| NCBI | Quality Control | Links |
|---|---|---|
| Actinobaculum | ||
| Alicyclobacillus | ||
| Gallicola | ||
| Helcococcus | ||
| Leptolyngbya | ||
| Porphyromonas | ||
| Sneathia |
Revision editor(s): Ojotuleonalo, Peace Sandy, Folakunmi
Signature 2
Curated date: 2023/10/08
Curator: Ojotuleonalo
Revision editor(s): Ojotuleonalo, Peace Sandy, Folakunmi
Source: Figure 5C
Description: Urinary microbiomes that were significantly more decreased in the samples of female patients with OAB (Over Active Bladder) with anxiety compared to the samples of female patients with OAB without anxiety.
Abundance in Group 1: decreased abundance in Overactive Bladder (OAB) with anxiety
| NCBI | Quality Control | Links |
|---|---|---|
| Agrobacterium | ||
| Burkholderia | ||
| Collinsella | ||
| Cryocola | ||
| Methanobrevibacter | ||
| Psychrobacter |
Revision editor(s): Ojotuleonalo, Peace Sandy, Folakunmi
