Urinary Microbiome and Psychological Factors in Women with Overactive Bladder/Experiment 3
From BugSigDB
Reviewed Marked as Reviewed by Folakunmi on 2024-1-18
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Female urethra Urethra feminina,Urethra muliebris,Female urethra,female urethra
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Depressive disorder depression,melancholia,melancholias,mental depression,syndrome, depressive,syndromes, depressive,Depressive disorder,depressive disorder
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Overactive Bladder (OAB) without depression
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Overactive Bladder (OAB) with depression
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Adult patients aged 18 or above, diagnosed with OAB and have anxiety
- Group 0 sample size Number of subjects in the control (unexposed) group
- 16
- Group 1 sample size Number of subjects in the case (exposed) group
- 14
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- LEfSe
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
- LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
- 2.5
Alpha Diversity
- Pielou Quantifies how equal the community is numerically
- increased
- Shannon Estimator of species richness and species evenness: more weight on species richness
- decreased
- Chao1 Abundance-based estimator of species richness
- decreased
- Simpson Estimator of species richness and species evenness: more weight on species evenness
- decreased
- Richness Number of species
- decreased
Signature 1
Reviewed Marked as Reviewed by Folakunmi on 2024-1-18
Source: Figure 5D
Description: Urinary microbiomes that were significantly decreased in the samples of female patients with OAB (Over Active Bladder) with depression compared to the samples of female patients with OAB without depression
Abundance in Group 1: decreased abundance in Overactive Bladder (OAB) with depression
| NCBI | Quality Control | Links |
|---|---|---|
| Clostridium | ||
| Actinobaculum | ||
| Pedobacter | ||
| Sporobacterium sp. WAL 1855D |
Revision editor(s): Folakunmi
