The gut-microbiota-brain axis in a Spanish population in the aftermath of the COVID-19 pandemic: microbiota composition linked to anxiety, trauma, and depression profiles/Experiment 1
From BugSigDB
Reviewed Marked as Reviewed by ChiomaBlessing on 2024-2-20
Curated date: 2023/10/29
Curator: Wangui Thuo
Revision editor(s): Wangui Thuo, Chinelsy, ChiomaBlessing
Subjects
- Location of subjects
- Spain
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Psychiatric disorder disease of mental health,mental disorder,mental dysfunction,mental illness,Psychiatric disease,Psychiatric disorder,psychiatric disorder
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Individuals without the comorbid state
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Individuals with comorbid PTSD + depression + state + trait anxiety symptoms (Comorbidity with Psychiatric Symptoms)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- This group included individuals with comorbid PTSD, depression, state and trait anxiety symptoms
- Group 0 sample size Number of subjects in the control (unexposed) group
- 190
- Group 1 sample size Number of subjects in the case (exposed) group
- 8
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- 6 months.
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V3-V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- Mann-Whitney (Wilcoxon)
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
- Confounders controlled for Confounding factors that have been accounted for by stratification or model adjustment
- age, body mass index, inflammatory bowel disease, sex, irritable bowel syndrome, Confounders controlled for: "celiac disease" is not in the list (abnormal glucose tolerance, acetaldehyde, acute graft vs. host disease, acute lymphoblastic leukemia, acute myeloid leukemia, adenoma, age, AIDS, alcohol consumption measurement, alcohol drinking, ...) of allowed values.celiac disease, Confounders controlled for: "Bernard-Soulier syndrome" is not in the list (abnormal glucose tolerance, acetaldehyde, acute graft vs. host disease, acute lymphoblastic leukemia, acute myeloid leukemia, adenoma, age, AIDS, alcohol consumption measurement, alcohol drinking, ...) of allowed values.Bernard-Soulier syndrome
Signature 1
Reviewed Marked as Reviewed by ChiomaBlessing on 2024-2-20
Source: Figure 4A
Description: Relative abundance of taxa in individuals with comorbid PTSD + depression + state and trait anxiety symptoms compared to those without the comorbid state
Abundance in Group 1: decreased abundance in Individuals with comorbid PTSD + depression + state + trait anxiety symptoms (Comorbidity with Psychiatric Symptoms)
| NCBI | Quality Control | Links |
|---|---|---|
| Fusicatenibacter saccharivorans |
Revision editor(s): ChiomaBlessing
