Delayed gut microbiota maturation in the first year of life is a hallmark of pediatric allergic disease/Experiment 1
From BugSigDB
Reviewed Marked as Reviewed by Folakunmi on 2024-1-29
Subjects
- Location of subjects
- Canada
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Dermatitis , Asthma , Food allergy , Allergic rhinitis inflammation of skin,inflammation of the skin,inflammation of zone of skin,inflammatory skin disease,skin inflammation,zone of skin inflammation,Dermatitis,dermatitis,Airway hyperreactivity,asthma,Asthma (disorder),Asthma NOS,Asthma NOS (disorder),ASTHMA NOS W (AC) EXAC,Asthma unspecified,Asthma unspecified (disorder),Asthma, Bronchial,Asthma, unspecified,Asthma, unspecified type, with acute exacerbation,Asthma, unspecified type, without mention of status asthmaticus,Asthmas,Asthmatic,BHR - Bronchial hyperreactivity,Bronchial asthma,Bronchial Hyperreactivities,Bronchial hyperreactivity,bronchial hyperreactivity,Bronchial hyperresponsiveness,Bronchial hypersensitivity,chronic obstructive asthma,chronic obstructive asthma with acute exacerbation,chronic obstructive asthma with status asthmaticus,DUST PNEUMONOPATHY NEC,Exercise induced asthma,exercise induced asthma,Exercise-induced asthma,exercise-induced asthma,Exercise-induced asthma (disorder),Hyperreactive airway disease,Hyperreactive airways disease,Hyperreactivities, Bronchial,Hyperreactivity, Bronchial,Other forms of asthma,Pneumonopathy due to inhalation of other dust,Pneumopathy due to inhalation of other dust,Pneumopathy due to inhalation of other dust (disorder),Pneumopathy due to inhalation of other dust NOS,Pneumopathy due to inhalation of other dust NOS (disorder),Asthma,Food Hypersensitivity,Food intolerance,Food allergy,food allergy,allergic form of rhinitis,allergic rhinitis,Alrh,atopic rhinitis,non-seasonal allergic rhinitis,Perenial allergic rhinitis,perennial allergic rhinitis,pollenosis,seasonal allergic rhinitis,Allergic rhinitis
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Healthy controls
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Allergic Children
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Children diagnosed by an expert physician at the 5-year scheduled visit with one or more allergic disorders.
- Group 0 sample size Number of subjects in the control (unexposed) group
- 523
- Group 1 sample size Number of subjects in the case (exposed) group
- 592
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- No Antibiotics exclusion was mentioned
Lab analysis
- Sequencing type
- WMS
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- Not specified
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- Random Forest Analysis
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
- Matched on Factors on which subjects have been matched on in a case-control study
- age
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- decreased
Signature 1
Reviewed Marked as Reviewed by Folakunmi on 2024-1-29
Curated date: 2023/10/11
Curator: Nwajei Edgar
Revision editor(s): Nwajei Edgar, Peace Sandy, Folakunmi
Source: figure 4C
Description: Comparing species abundance within the 1-year microbiota between children who did or did not receive an allergic diagnosis at 5 years
Abundance in Group 1: decreased abundance in Allergic Children
| NCBI | Quality Control | Links |
|---|---|---|
| Anaerobutyricum hallii | ||
| Anaerostipes hadrus | ||
| Blautia wexlerae | ||
| Fusicatenibacter saccharivorans |
Revision editor(s): Nwajei Edgar, Peace Sandy, Folakunmi
Signature 2
Reviewed Marked as Reviewed by Folakunmi on 2024-1-29
Curated date: 2023/10/11
Curator: Nwajei Edgar
Revision editor(s): Nwajei Edgar, Peace Sandy, Folakunmi
Source: figure 4C
Description: Comparing species abundance within the 1-year microbiota between children who did or did not receive an allergic diagnosis at 5 years
Abundance in Group 1: increased abundance in Allergic Children
| NCBI | Quality Control | Links |
|---|---|---|
| Eggerthella lenta | ||
| Enterococcus faecalis | ||
| Escherichia coli | ||
| [Clostridium] innocuum | ||
| [Clostridium] nexile |
Revision editor(s): Nwajei Edgar, Peace Sandy, Folakunmi
