Gut microbiome and atrial fibrillation-results from a large population-based study/Experiment 3
From BugSigDB
Needs review
Subjects
- Location of subjects
- Finland
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Atrial fibrillation A-fib,AF,AF - Atrial fibrillation,AFib,atrial fibrillation,atrial fibrillation (disease),Atrial fibrillation (disorder),Atrial Fibrillations,Auricular Fibrillation,Auricular Fibrillations,Fibrillation, Atrial,Fibrillation, Auricular,Fibrillations, Atrial,Fibrillations, Auricular,Atrial fibrillation
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Individuals with Incident Atrial Fibrillation (AF)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Incident AF refers to new cases of atrial fibrillation that occurred during the follow-up period of the study, among individuals who did not have a history of atrial fibrillation at baseline.
- Group 1 sample size Number of subjects in the case (exposed) group
- 6923
Lab analysis
- Sequencing type
- WMS
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- Not specified
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- centered log-ratio
- Statistical test
- Cox Proportional-Hazards Regression
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
- Matched on Factors on which subjects have been matched on in a case-control study
- age, body mass index, sex
- Confounders controlled for Confounding factors that have been accounted for by stratification or model adjustment
- age, body mass index, diabetes mellitus, sex
Signature 1
Needs review
Source: Table 4
Description: Differential abundance of microorganism in incident atrial fibrillation in Cox regression analyses considering the hazard ratio.
Abundance in Group 1: decreased abundance in
| NCBI | Quality Control | Links |
|---|---|---|
| Alistipes | ||
| Barnesiella | ||
| Enterococcus | ||
| Odoribacter | ||
| Paraprevotella | ||
| Sanguibacter |
Revision editor(s): Iram jamshed
Signature 2
Needs review
Source: Table 4
Description: Differential abundance of microorganism in incident atrial fibrillation in Cox regression analyses considering the hazard ratio.
Abundance in Group 1: increased abundance in
| NCBI | Quality Control | Links |
|---|---|---|
| Clostridium | ||
| Collinsella | ||
| Enorma | ||
| Solobacterium |
Revision editor(s): Iram jamshed
