Changes and significance of gut microbiota in children with focal epilepsy before and after treatment/Experiment 3
From BugSigDB
Reviewed Marked as Reviewed by Folakunmi on 2024-1-17
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Response to oxcarbazepine Response to oxcarbazepine,response to oxcarbazepine
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- pre-treatment (focal epilepsy)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- post-treatment (focal epilepsy)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- This subgroup comprises individuals from the case group who have undergone a specific treatment, in this case, three months of treatment with oxcarbazepine (OXC).
- Group 0 sample size Number of subjects in the control (unexposed) group
- 14
- Group 1 sample size Number of subjects in the case (exposed) group
- 10
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- 2 weeks
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V4-V5
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- LEfSe
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- unchanged
- Chao1 Abundance-based estimator of species richness
- unchanged
- Simpson Estimator of species richness and species evenness: more weight on species evenness
- unchanged
- Richness Number of species
- unchanged
Signature 1
Reviewed Marked as Reviewed by Folakunmi on 2024-1-17
Source: Fig.3D
Description: Diversity and relative abundance of gut microbiota between the groups before and after treatment
Abundance in Group 1: increased abundance in post-treatment (focal epilepsy)
| NCBI | Quality Control | Links |
|---|---|---|
| Lentisphaeria | ||
| Oscillibacter | ||
| Sutterellaceae | ||
| Victivallaceae | ||
| Victivallales | ||
| Victivallis | ||
| Oscillibacter sp. G2 | ||
| Victivallaceae bacterium NML 080035 | ||
| uncultured rumen bacterium |
Revision editor(s): Chinelsy
Signature 2
Reviewed Marked as Reviewed by Folakunmi on 2024-1-17
Source: Fig.3D
Description: Diversity and relative abundance of gut microbiota between the groups before and after treatment
Abundance in Group 1: decreased abundance in post-treatment (focal epilepsy)
Revision editor(s): Chinelsy
