A Combined Analysis of Gut and Skin Microbiota in Infants with Food Allergy and Atopic Dermatitis: A Pilot Study/Experiment 4
From BugSigDB
Reviewed Marked as Reviewed by Folakunmi on 2023-12-26
Subjects
- Location of subjects
- Poland
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Food allergy , Dermatitis Food Hypersensitivity,Food intolerance,Food allergy,food allergy,inflammation of skin,inflammation of the skin,inflammation of zone of skin,inflammatory skin disease,skin inflammation,zone of skin inflammation,Dermatitis,dermatitis
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Control group
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Infants with Allergy Symptoms
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- All infants with Allergy symptoms including Food Allergy, Atopic dermatitis, and both Atopic dermatitis and Food Allergy
- Group 0 sample size Number of subjects in the control (unexposed) group
- 28
- Group 1 sample size Number of subjects in the case (exposed) group
- 59
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- 1 month
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V3-V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- Spearman Correlation
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- unchanged
- Richness Number of species
- unchanged
Signature 1
Reviewed Marked as Reviewed by Folakunmi on 2023-12-26
Source: Table 5
Description: OTUs whose abundance on skin and in feces is correlated
Abundance in Group 1: increased abundance in Infants with Allergy Symptoms
| NCBI | Quality Control | Links |
|---|---|---|
| Streptococcus sp. | ||
| Gemella | ||
| Bifidobacterium scardovii | ||
| Rothia mucilaginosa | ||
| Lactobacillus gasseri |
Revision editor(s): Folakunmi
Signature 2
Reviewed Marked as Reviewed by Folakunmi on 2023-12-26
Source: Table 5
Description: OTUs whose abundance on skin and in feces is correlated
Abundance in Group 1: decreased abundance in Infants with Allergy Symptoms
| NCBI | Quality Control | Links |
|---|---|---|
| Acinetobacter sp. | ||
| Streptococcus sp. | ||
| Lactobacillus gasseri | ||
| Haemophilus haemolyticus | ||
| Bacteroides ovatus | ||
| Schaalia odontolytica | ||
| Actinomyces graevenitzii |
Revision editor(s): Folakunmi
