Differences in gut microbiota between allergic rhinitis, atopic dermatitis, and skin urticaria: A pilot study/Experiment 2
Subjects
- Location of subjects
- Taiwan
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Eczema , Allergic rhinitis Eczema,eczema,allergic form of rhinitis,allergic rhinitis,Alrh,atopic rhinitis,non-seasonal allergic rhinitis,Perenial allergic rhinitis,perennial allergic rhinitis,pollenosis,seasonal allergic rhinitis,Allergic rhinitis
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Allergic rhinitis
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Atopic dermatitis (eczema)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Patients with atopic dermatitis (eczema)
- Group 0 sample size Number of subjects in the control (unexposed) group
- 9
- Group 1 sample size Number of subjects in the case (exposed) group
- 19
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- Those with a history of antibiotics
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V3-V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- LEfSe
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- increased
- Chao1 Abundance-based estimator of species richness
- unchanged
- Richness Number of species
- unchanged
Signature 1
Source: Fig 5
Description: Phylum Firmicutes, class Clostridia, order Clostridiales, families Ruminococcaceae and Lachnospiraceae, genera Eubacterium and atopobium were 10,000 times higher than in the allergic rhinitis (rhinitis) subgroup. Species Bacteroids Plebeius DSM 17135 and genus Prevotella were 10,000 times higher than in the urticaria (hives) subgroup. Order Bacteroidales, class Bacteroidia, phylum Bacteroidetes, and genus Romboutsia were 10,000 times higher than in the atopic dermatitis (eczema) subgroup.
Abundance in Group 1: increased abundance in Atopic dermatitis (eczema)
| NCBI | Quality Control | Links |
|---|---|---|
| Bacteroidales | ||
| Bacteroidia | ||
| Romboutsia | ||
| Sutterella |
Revision editor(s): Peace Sandy
Signature 2
Source: Figure 5
Description: Phylum Firmicutes, class Clostridia, order Clostridiales, families Ruminococcaceae and Lachnospiraceae, genera Eubacterium and atopobium were 10,000 times higher than in the allergic rhinitis (rhinitis) subgroup. Species Bacteroids Plebeius DSM 17135 and genus Prevotella were 10,000 times higher than in the urticaria (hives) subgroup. Order Bacteroidales, class Bacteroidia, phylum Bacteroidetes, and genus Romboutsia were 10,000 times higher than in the atopic dermatitis (eczema) subgroup.
Abundance in Group 1: decreased abundance in Atopic dermatitis (eczema)
| NCBI | Quality Control | Links |
|---|---|---|
| Atopobium | ||
| Bacillota | ||
| Clostridia | ||
| Eubacteriales | ||
| Eubacterium coprostanoligenes | ||
| Lachnospiraceae |
Revision editor(s): Peace Sandy
