A Pilot Microbiota Study in Parkinson's Disease Patients versus Control Subjects, and Effects of FTY720 and FTY720-Mitoxy Therapies in Parkinsonian and Multiple System Atrophy Mouse Models/Experiment 4
From BugSigDB
Subjects
- Location of subjects
- United States of America
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Mus musculus
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Multiple system atrophy autonomic failure, Pure,hypotension, orthostatic,MSA,multiple system atrophy,Multiple system atrophy (disorder),multisystem atrophy,orthostatic hypotension syndrome,Shy-Drager Syndrome,Shy-Drager syndrome,Shy-dragger syndrome (formerly),Shy-McGee-Drager syndrome,susceptibility to multiple system atrophy 1,Multiple system atrophy
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Wild Type
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Multiple system atrophy
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- 10 - 11 month old transgenic (Tg) mice with with Multiple system atrophy that express CNP-aSyn.
- Group 0 sample size Number of subjects in the control (unexposed) group
- 5
- Group 1 sample size Number of subjects in the case (exposed) group
- 5
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V3-V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Statistical test
- Spearman Correlation
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
Signature 1
Source: Table 1 (column D)
Description: Relative abundance of relevant taxa shared with parkinsonian and multiple system atrophy mouse models.
Abundance in Group 1: increased abundance in Multiple system atrophy
| NCBI | Quality Control | Links |
|---|---|---|
| Bacillota | ||
| Bacteroidia |
Revision editor(s): Flo
