Gut microbiota regulate Alzheimer's disease pathologies and cognitive disorders via PUFA-associated neuroinflammation/Experiment 1
From BugSigDB
Reviewed Marked as Reviewed by Folakunmi on 2024-3-26
Subjects
- Location of subjects
- United States of America
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Mus musculus
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Alzheimer's disease [X]Dementia in Alzheimer's disease,[X]Dementia in Alzheimer's disease (disorder),AD,AD - Alzheimer's disease,Alzheimer Dementia,Alzheimer dementia,Alzheimer Dementia, Presenile,ALZHEIMER DIS,Alzheimer Disease,Alzheimer disease,Alzheimer disease, familial,Alzheimer Type Dementia,Alzheimer's,Alzheimer's Dementia,Alzheimer's dementia,Alzheimer's disease,Alzheimer's disease (disorder),Alzheimer's disease, NOS,Alzheimers,Alzheimers Dementia,Alzheimers dementia,ALZHEIMERS DIS,Alzheimers disease,DAT - Dementia Alzheimer's type,Dementia in Alzheimer's disease,Dementia in Alzheimer's disease (disorder),Dementia in Alzheimer's disease, unspecified (disorder),Dementia of the Alzheimer's type,Dementia, Alzheimer Type,Dementia, Presenile,Dementia, Presenile Alzheimer,Disease, Alzheimer,Disease, Alzheimer's,Presenile Alzheimer Dementia,sporadic Alzheimer's disease,alzheimer's disease
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Healthy control FMT mice
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Alzheimer's disease FMT mice
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- ex germ-free mice inoculated with fecal samples from human Alzheimer's disease donors
- Group 0 sample size Number of subjects in the control (unexposed) group
- 3
- Group 1 sample size Number of subjects in the case (exposed) group
- 3
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- human donors had no antimicrobial exposure within the preceding 4 weeks
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- ANOVA
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
- Matched on Factors on which subjects have been matched on in a case-control study
- age
Signature 1
Reviewed Marked as Reviewed by Folakunmi on 2024-3-26
Source: Figure 5
Description: Microbiome analysis in humanised ex-germ-free 3xTg mouse stool, revealing the significant abundance in the faeces from human AD fecal inoculated germ-free mice and faeces from healthy human inoculated germ-free mice
Abundance in Group 1: increased abundance in Alzheimer's disease FMT mice
| NCBI | Quality Control | Links |
|---|---|---|
| Bacteroides fragilis | ||
| Bacteroides intestinalis | ||
| Bacteroides xylanisolvens |
Revision editor(s): Graycepaul, Welile, Folakunmi
Signature 2
Reviewed Marked as Reviewed by Folakunmi on 2024-3-26
Curated date: 2024/03/09
Curator: Graycepaul
Revision editor(s): Graycepaul, Welile, Muqtadirat, Folakunmi
Source: Figure 5
Description: Microbiome analysis in humanised ex-germ-free 3xTg mouse stool, revealing the significant abundance in the faeces from human AD fecal inoculated germ-free mice and faeces from healthy human inoculated germ-free mice
Abundance in Group 1: decreased abundance in Alzheimer's disease FMT mice
| NCBI | Quality Control | Links |
|---|---|---|
| Enterocloster bolteae | ||
| Parabacteroides goldsteinii |
Revision editor(s): Graycepaul, Welile, Muqtadirat, Folakunmi
