Maternal influence on the fetal microbiome in a population-based study of the first-pass meconium/Experiment 4
From BugSigDB
Reviewed Marked as Reviewed by Shaimaa Elsafoury on 2021/02/09
Subjects
- Location of subjects
- Finland
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Meconium Meconium,meconium
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Cesarean section caesarean section,Cesarean section,cesarean section
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Furry pets at home (NO)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Furry pets at home (YES)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Mothers who have furry pets at home during pregnancy
- Group 0 sample size Number of subjects in the control (unexposed) group
- 108
- Group 1 sample size Number of subjects in the case (exposed) group
- 104
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- None.
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V4-V5
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Ion Torrent
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- Mann-Whitney (Wilcoxon)
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
- Confounders controlled for Confounding factors that have been accounted for by stratification or model adjustment
- antimicrobial agent during labor, delivery procedure, probiotics during pregnancy
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- increased
- Richness Number of species
- increased
Signature 1
Reviewed Marked as Reviewed by Shaimaa Elsafoury on 2021/02/09
Source: Table 4
Description: Effect of furry pets at home on the microbiome in the group who have furry pets at home (YES) compared to the group who don't have (NO)
Abundance in Group 1: increased abundance in Furry pets at home (YES)
| NCBI | Quality Control | Links |
|---|---|---|
| Bacteroidota | ||
| Faecalibacterium |
Revision editor(s): WikiWorks, ChiomaBlessing
Signature 2
Reviewed Marked as Reviewed by Shaimaa Elsafoury on 2021/02/09
Source: Table 4
Description: Effect of furry pets at home on the microbiome in the group who have furry pets at home (YES) compared to the group who don't have (NO)
Abundance in Group 1: decreased abundance in Furry pets at home (YES)
| NCBI | Quality Control | Links |
|---|---|---|
| Bacillota | ||
| Staphylococcus |
Revision editor(s): WikiWorks, ChiomaBlessing
