Orally administered neohesperidin attenuates MPTP-induced neurodegeneration by inhibiting inflammatory responses and regulating intestinal flora in mice/Experiment 1

From BugSigDB


Reviewed Marked as Reviewed by Svetlana up on 2025-3-28

Curated date: 2025/03/25

Curator: MyleeeA

Revision editor(s): MyleeeA

Subjects

Location of subjects
China
Host species Species from which microbiome was sampled. Contact us to have more species added.
Mus musculus
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Treatment Treatment,treatment
Group 0 name Corresponds to the control (unexposed) group for case-control studies
Saline
Group 1 name Corresponds to the case (exposed) group for case-control studies
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) group administered with MPTP 25 mg kg−1 dissolved in saline, intraperitoneally
Group 0 sample size Number of subjects in the control (unexposed) group
6
Group 1 sample size Number of subjects in the case (exposed) group
6

Lab analysis

Sequencing type
16S
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
Not specified

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
relative abundances
Statistical test
ANOVA
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
No

Alpha Diversity

Chao1 Abundance-based estimator of species richness
unchanged
Richness Number of species
unchanged
Faith Phylogenetic diversity, takes into account phylogenetic distance of all taxa identified in a sample
unchanged

Signature 1

Reviewed Marked as Reviewed by Svetlana up on 2025-3-28

Curated date: 2025/03/25

Curator: MyleeeA

Revision editor(s): MyleeeA

Source: Figure 5D, F and H

Description: Differences in the abundance of microbial taxa between Saline and MPTP groups.

Abundance in Group 1: increased abundance in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

NCBI Quality ControlLinks
Actinomycetota
Adlercreutzia
Allobaculum
Desulfovibrionaceae
Erysipelotrichaceae
Oscillospira
Pseudomonadota
Psychrobacter

Revision editor(s): MyleeeA

Signature 2

Reviewed Marked as Reviewed by Svetlana up on 2025-3-28

Curated date: 2025/03/25

Curator: MyleeeA

Revision editor(s): MyleeeA

Source: Figure 5F and H

Description: Differences in the abundance of microbial taxa between Saline and MPTP groups.

Abundance in Group 1: decreased abundance in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

NCBI Quality ControlLinks
Lactobacillaceae
Lactobacillus

Revision editor(s): MyleeeA