Orally administered neohesperidin attenuates MPTP-induced neurodegeneration by inhibiting inflammatory responses and regulating intestinal flora in mice/Experiment 1
From BugSigDB
Reviewed Marked as Reviewed by Svetlana up on 2025-3-28
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Mus musculus
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Treatment Treatment,treatment
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Saline
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) group administered with MPTP 25 mg kg−1 dissolved in saline, intraperitoneally
- Group 0 sample size Number of subjects in the control (unexposed) group
- 6
- Group 1 sample size Number of subjects in the case (exposed) group
- 6
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- Not specified
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- ANOVA
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
Alpha Diversity
- Chao1 Abundance-based estimator of species richness
- unchanged
- Richness Number of species
- unchanged
- Faith Phylogenetic diversity, takes into account phylogenetic distance of all taxa identified in a sample
- unchanged
Signature 1
Reviewed Marked as Reviewed by Svetlana up on 2025-3-28
Source: Figure 5D, F and H
Description: Differences in the abundance of microbial taxa between Saline and MPTP groups.
Abundance in Group 1: increased abundance in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
NCBI | Quality Control | Links |
---|---|---|
Actinomycetota | ||
Adlercreutzia | ||
Allobaculum | ||
Desulfovibrionaceae | ||
Erysipelotrichaceae | ||
Oscillospira | ||
Pseudomonadota | ||
Psychrobacter |
Revision editor(s): MyleeeA
Signature 2
Reviewed Marked as Reviewed by Svetlana up on 2025-3-28
Source: Figure 5F and H
Description: Differences in the abundance of microbial taxa between Saline and MPTP groups.
Abundance in Group 1: decreased abundance in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
NCBI | Quality Control | Links |
---|---|---|
Lactobacillaceae | ||
Lactobacillus |
Revision editor(s): MyleeeA