Gut microbiome alterations precede graft rejection in kidney transplantation patients/Experiment 5

From BugSigDB


Needs review

Curated date: 2025/04/06

Curator: MyleeeA

Revision editor(s): MyleeeA

Subjects

Location of subjects
Germany
Host species Species from which microbiome was sampled. Contact us to have more species added.
Homo sapiens
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Chronic kidney disease chronic kidney disease,chronic kidney failure,Chronic Kidney Insufficiencies,Chronic Kidney Insufficiency,chronic renal disease,Chronic Renal Failure,chronic renal failure syndrome,Chronic Renal Insufficiencies,chronic renal insufficiency,CKD,CKD - chronic kidney disease,Disease, End-Stage Kidney,Disease, End-Stage Renal,END STAGE KIDNEY DIS,End Stage Kidney Disease,END STAGE RENAL DIS,End Stage Renal Disease,End-Stage Kidney Disease,End-Stage Renal Disease,End-Stage Renal Failure,ESRD,kidney disease, chronic,Kidney Disease, End-Stage,Kidney Failure, Chronic,Kidney Insufficiencies, Chronic,Kidney Insufficiency, Chronic,RENAL DIS END STAGE,Renal Disease, End Stage,Renal Disease, End-Stage,renal failure - chronic,Renal Failure, Chronic,Renal Failure, End Stage,Renal Failure, End-Stage,Renal Insufficiencies, Chronic,Renal Insufficiency, Chronic,Chronic kidney disease
Group 0 name Corresponds to the control (unexposed) group for case-control studies
Healthy controls
Group 1 name Corresponds to the case (exposed) group for case-control studies
Chronic Kidney Disease (CKD)
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
Patients with Chronic Kidney Disease (CKD) from an already published datasets.
Group 0 sample size Number of subjects in the control (unexposed) group
479
Group 1 sample size Number of subjects in the case (exposed) group
217

Lab analysis

Sequencing type
16S
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
V3-V4
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
Illumina

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
relative abundances
Statistical test
Mann-Whitney (Wilcoxon)
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
Yes


Signature 1

Needs review

Curated date: 2025/04/08

Curator: MyleeeA

Revision editor(s): MyleeeA

Source: Figure 6B

Description: Differential abundance analysis of bacterial taxa between Chronic Kidney Disease (CKD) and Healthy Controls.

Abundance in Group 1: increased abundance in Chronic Kidney Disease (CKD)

NCBI Quality ControlLinks
Streptococcus

Revision editor(s): MyleeeA

Signature 2

Needs review

Curated date: 2025/04/08

Curator: MyleeeA

Revision editor(s): MyleeeA

Source: Figure 6B

Description: Differential abundance analysis of bacterial taxa between Chronic Kidney Disease (CKD) and Healthy Controls.

Abundance in Group 1: decreased abundance in Chronic Kidney Disease (CKD)

NCBI Quality ControlLinks
Blautia
Faecalibacterium

Revision editor(s): MyleeeA