Why do babies cry? Exploring the role of the gut microbiota in infantile colic, constipation, and cramps in the KOALA birth cohort study/Experiment 24

From BugSigDB


Needs review

Curated date: 2025/05/02

Curator: MyleeeA

Revision editor(s): MyleeeA

Subjects

Location of subjects
Netherlands
Host species Species from which microbiome was sampled. Contact us to have more species added.
Homo sapiens
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Treatment Treatment,treatment
Group 0 name Corresponds to the control (unexposed) group for case-control studies
Colic:Wessel No Antibiotics crude 4-7 months
Group 1 name Corresponds to the case (exposed) group for case-control studies
Colic:Wessel No Antibiotics adjusted 4-7 months
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
Colic:Wessel covariate Adjusted No Antibiotics 4-7 months group
Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
3 months

Lab analysis

Sequencing type
16S
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
V4
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
Illumina

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
centered log-ratio
Statistical test
Logistic Regression
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
Yes

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
unchanged
Richness Number of species
unchanged

Signature 1

Needs review

Curated date: 2025/05/03

Curator: MyleeeA

Revision editor(s): MyleeeA

Source: Figure 5C

Description: Results of regression model testing associations between Colic:Wessel No Antibiotics crude 4-7 months and Colic:Wessel No Antibiotics adjusted 4-7 months.

Abundance in Group 1: increased abundance in Colic:Wessel No Antibiotics adjusted 4-7 months

NCBI Quality ControlLinks
Mediterraneibacter gnavus

Revision editor(s): MyleeeA

Signature 2

Needs review

Curated date: 2025/05/03

Curator: MyleeeA

Revision editor(s): MyleeeA

Source: Figure 5C

Description: Results of regression model testing associations between Colic:Wessel No Antibiotics crude 4-7 months and Colic:Wessel No Antibiotics adjusted 4-7 months.

Abundance in Group 1: decreased abundance in Colic:Wessel No Antibiotics adjusted 4-7 months

NCBI Quality ControlLinks
Lactobacillus
Bifidobacterium

Revision editor(s): MyleeeA