Dysbiosis of Gut Microbiota and Short-Chain Fatty Acids in Acute Ischemic Stroke and the Subsequent Risk for Poor Functional Outcomes/Experiment 5
From BugSigDB
Reviewed Marked as Reviewed by Folakunmi on 2024-11-13
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Ischemic stroke Ischaemic stroke,Ischemic stroke,ischemic stroke
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Healthy control group (HC)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Acute ischemic stroke (AIS)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- All acute ischemic stroke patients with ischemic stroke onset within 48 hours.
- Group 0 sample size Number of subjects in the control (unexposed) group
- 92
- Group 1 sample size Number of subjects in the case (exposed) group
- 140
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- No antibiotics, prebiotics or probiotics taken in the past 3 months.
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- LEfSe
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
- LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
- 2.5
Signature 1
Reviewed Marked as Reviewed by Folakunmi on 2024-11-13
Source: Figure 3
Description: Comparison of the abundance of short-chain fatty acid-producing gut microbiota between healthy controls and Acute Ischemic Stroke patients according to taxonomic classification and LEfSe analysis.
Abundance in Group 1: increased abundance in Acute ischemic stroke (AIS)
| NCBI | Quality Control | Links |
|---|---|---|
| Akkermansia | ||
| Enterobacteriaceae | ||
| Lactobacillaceae | ||
| Porphyromonadaceae |
Signature 2
Reviewed Marked as Reviewed by Folakunmi on 2024-11-13
Source: Figure 3
Description: Comparison of the abundance of short-chain fatty acid-producing microbiota in healthy controls versus acute ischemic stroke patients according to taxonomic classification and LEfSe analysis.
Abundance in Group 1: decreased abundance in Acute ischemic stroke (AIS)
| NCBI | Quality Control | Links |
|---|---|---|
| Anaerostipes | ||
| Bacteroides | ||
| Blautia | ||
| Faecalibacterium | ||
| Lachnospiraceae | ||
| Roseburia |
