Oral, Vaginal, and Stool Microbial Signatures in Patients With Endometriosis as Potential Diagnostic Non-Invasive Biomarkers: A Prospective Cohort Study/Experiment 10
From BugSigDB
Subjects
- Location of subjects
- Australia
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Mouth Adult mouth,Cavital oralis,Cavitas oris,Cavum oris,Mouth cavity,Oral region,Oral vestibule,Regio oralis,Rima oris,Stoma,Stomatodaeum,Trophic apparatus,Vestibule of mouth,Vestibulum oris,Mouth,mouth
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Endometriosis endometriosis,Endometriosis (clinical),endometriosis (disease),Endometriosis (disorder),Endometriosis (morphologic abnormality),ENDOMETRIOSIS NEC,Endometriosis NOS,Endometriosis NOS (disorder),Endometriosis of other specified sites,Endometriosis, site unspecified,Endometriosis
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Minimal/Mild endometriosis
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Moderate/Severe endometriosis
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Patients who underwent laparoscopy with confirmed endometriosis (ENDO) Stages 3 and 4 further grouped as Moderate/Severe endometriosis.
- Group 0 sample size Number of subjects in the control (unexposed) group
- 12
- Group 1 sample size Number of subjects in the case (exposed) group
- 9
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V3-V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- LEfSe
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
- LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
- 2.0
Signature 1
Source: Figure 6
Description: Microbial features that were detected to be differentially abundant using LEfSe analysis between patients with Minimal/Mild stage endometriosis and patients with Moderate/Severe endometriosis in oral samples.
Abundance in Group 1: increased abundance in Moderate/Severe endometriosis
| NCBI | Quality Control | Links |
|---|---|---|
| Fusobacterium |
Revision editor(s): MyleeeA
Signature 2
Source: Figure 6
Description: Microbial features that were detected to be differentially abundant using LEfSe analysis between patients with Minimal/Mild stage endometriosis and patients with Moderate/Severe endometriosis in oral samples.
Abundance in Group 1: decreased abundance in Moderate/Severe endometriosis
| NCBI | Quality Control | Links |
|---|---|---|
| Cardiobacterium |
Revision editor(s): MyleeeA
