Gut Microbiota Signatures in Gestational Anemia/Experiment 2
From BugSigDB
Reviewed Marked as Reviewed by Chinelsy on 2023-10-30
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Anemia anaemia,anemia,anemia (disease),Anemia
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- healthy controls (HC3 group)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- gestational anemia (GA3 group)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Gestational diseases are associated with altered intestinal microbiota in pregnant women in the third trimester.
- Group 0 sample size Number of subjects in the control (unexposed) group
- 56
- Group 1 sample size Number of subjects in the case (exposed) group
- 30
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- 4 weeks
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- Mann-Whitney (Wilcoxon)
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- Matched on Factors on which subjects have been matched on in a case-control study
- age, body mass index, gestational age, sex
Alpha Diversity
- Pielou Quantifies how equal the community is numerically
- unchanged
- Shannon Estimator of species richness and species evenness: more weight on species richness
- decreased
- Richness Number of species
- decreased
- Faith Phylogenetic diversity, takes into account phylogenetic distance of all taxa identified in a sample
- unchanged
Signature 1
Reviewed Marked as Reviewed by Chinelsy on 2023-10-30
Source: FIGURE 2C.
Description: Bacterial genera significantly enriched in the GA3 group compared to the HC3 group (third trimester).
Abundance in Group 1: increased abundance in gestational anemia (GA3 group)
| NCBI | Quality Control | Links |
|---|---|---|
| Atopobium | ||
| Catenibacterium | ||
| Clostridiaceae | ||
| Eggerthella |
Revision editor(s): Chinelsy, ChiomaBlessing
Signature 2
Reviewed Marked as Reviewed by ChiomaBlessing on 2024-2-1
Source: FIGURE 2C.
Description: Bacterial genera significantly enriched in the GA3 group compared to the HC3 group (third trimester).
Abundance in Group 1: decreased abundance in gestational anemia (GA3 group)
| NCBI | Quality Control | Links |
|---|---|---|
| Faecalibacterium | ||
| Ruminococcus | ||
| unclassified Mogibacterium | ||
| Oscillospiraceae | ||
| Eubacteriales | ||
| Anaerostipes | ||
| Gemmiger | ||
| Adlercreutzia |
Revision editor(s): ChiomaBlessing
